Functional Lung Avoidance SPECT-guided Radiation Therapy of Lung Cancer (ASPECT)

  • End date
    Dec 1, 2024
  • participants needed
  • sponsor
    University of Aarhus
Updated on 4 June 2022
ct scan
lung cancer
diagnostic procedures
thoracic disease
lung carcinoma


Study aims to determine if functional lung avoidance based on perfusion single photon emission (SPECT)/CT scan, improves toxicity outcomes for patients with advanced lung cancer undergoing chemo-radiotherapy. Functional avoidance implies a dose plan that takes functional distribution in the lung into account, and avoids highly functional lung volumes sparing them from radiation.


In this project, a novel method of safe radiotherapy delivery shall be tested for patients with lung cancer in a clinical setting. Functional avoidance radiotherapy is a new method that protect highly functional lung tissue from radiation, while delivering high dose radiotherapy to the lung tumour. Radiotherapy is usually based on a CT scan that does not account for functional variations in the lungs. Therefore, I hypothesize that using functional distribution in the lungs and avoiding irradiation of highly functional lung will improve treatment outcome for individual patients with lung cancer.

The objective of my project is to determine if functional image guided radiotherapy (functional avoidance radiotherapy) improves toxicity outcomes for patients with lung cancer undergoing curative chemo-radiotherapy in a prospective clinical trial.

To reach this objective, the impact of functional avoidance radiotherapy on pulmonary toxicity measured by the incidence and severity of radiation-induced lung disease shall be assessed. Additionally, loco-regional control, time to progression, overall survival, quality of life and radiation-induced molecular response in patients treated with functional avoidance radiotherapy shall be assessed and compared to patients receiving standard treatment.

Condition Lung Cancer, Radiation-Induced Disorder, Radiation Pneumonitis, Pulmonary Disease, Lung Function Decreased
Treatment Single-photon-emission CT scan
Clinical Study IdentifierNCT04676828
SponsorUniversity of Aarhus
Last Modified on4 June 2022


Yes No Not Sure

Inclusion Criteria

histologically verified lung cancer (small-cell and non-small cell lung cancer)
referred for radiotherapy with curative intent
radiation dose of 60-66 Gy given in 2-Gy fractions, other dose levels and fractionation schedules accepted, as per site standard
concurrent chemotherapy is accepted
patients with oligometastatic disease are allowed, where metastasis have been ablated with surgery or radiotherapy
receiving (chemo)-radiotherapy to the thoracic disease with curative intent
adults over 18, that have given oral and written informed consent before patient registration

Exclusion Criteria

concurrent immunotherapy
previous radiotherapy to the thorax
other uncontrolled malignancies; any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol
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