ALI Post Radiation Therapy in Patients With Lung and Esophageal Canter
-
- STATUS
- Recruiting
-
- days left to enroll
- 63
-
- participants needed
- 20
-
- sponsor
- M.D. Anderson Cancer Center
Summary
The goal of this clinical research study is to learn if giving autologous lymphocyte infusions to patients who are receiving chemotherapy and radiation for non-small cell lung cancer or esophageal cancer is safe and effective.
Description
The purpose of this study is to determine the safety and preliminary efficacy of un-manipulated autologous lymphocyte infusion (ALI) using the patient's own lymphocytes collected using apheresis, and infused after the completion of radiation/chemoradiation. Primary Objective To investigate the preliminary efficacy of autologous lymphocyte infusion (ALI) in improving the absolute lymphocyte counts in lung and esophageal cancer patients who had undergone chemo-radiation (CRT). Secondary Objectives
- To evaluate the feasibility and safety of ALI in patients who had undergone chemoradiation.
- To identify lymphocyte clonal populations in the tissue that are specific for tumor cells
- To identify immune reconstitution in the peripheral blood shaped by ALI.
- To conduct clonal analysis using T-cell receptor (TCR) sequencing from tumor and from peripheral blood.
Details
| Condition | Solid Tumor Malignancies |
|---|---|
| Treatment | Autologous lymphocyte infusion (ALI) |
| Clinical Study Identifier | NCT04668833 |
| Sponsor | M.D. Anderson Cancer Center |
| Last Modified on | 4 October 2022 |
How to participate?
,
You have contacted , on
Your message has been sent to the study team at ,
What happens next?
- You can expect the study team to contact you via email or phone in the next few days.
- Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.
You are contacting
Primary Contact
Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.
Learn moreIf you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.
Learn moreComplete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.
Learn moreSimilar trials to consider
Browse trials for
Not finding what you're looking for?
Sign up as a volunteer to stay informed
Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.
Sign up as volunteer