This study intends to evaluate the efficacy and safety of hepatic arterial infusion chemotherapy of oxaliplatin, 5-fluorouracil and leucovorin plus lenvatinib and Sintilimab for patients hepatocellular carcinoma and portal vein tumor thrombus.
Hepatic arterial infusion chemotherapy (HAIC) of oxaliplatin, 5-fluorouracil and leucovorin was effective and safe for hepatocellular carcinoma. Lenvatinib was non-inferior to sorafenib in overall survival in untreated advanced hepatocellular carcinoma, and Sintilimab, an programmed cell death protein-1 (PD-1) antibody, was effective and tolerable in patients with hepatocellular carcinoma and portal vein tumor thrombus. No study has evaluated HAIC plus Lenvatinib and Sintilimab. Thus, the investigators carried out this prospective, single-arm study to find out it.
| Condition | LIVER DISEASE, LIVER DISEASE, Liver Disorders, HEPATIC NEOPLASM, Liver Cancer, Neoplasm of unspecified nature of digestive system, Digestive System Neoplasms, HEPATOCELLULAR CARCINOMA, Portal Vein Tumor Thrombus, Liver Cancer, Liver Disorders, Digestive System Neoplasms, Sintilimab, hepatoma, tumor liver, liver tumor, liver tumours, liver cell carcinoma |
|---|---|
| Treatment | Lenvatinib, Hepatic arterial infusion chemotherapy, Sintilimab |
| Clinical Study Identifier | NCT04618367 |
| Sponsor | Sun Yat-sen University |
| Last Modified on | 27 January 2023 |
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