Anlotinib to Malignant Brainstem Glioma

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  • sponsor
    Zhejiang Cancer Hospital
Updated on 1 February 2023


This study is a single-arm, open-label, phase II study of anlotinib combined with radiation in the treatment of patients with malignant brainstem glioma. Twenty five patients will be enrolled in the study who is diagonsis with malignant brainstem glioma. The primary objective includes disease control rate (DCR), the role of antinib combined with radiotherapy in improving quality of life and 6-month progression-free survival rate. The secondary objective include overall survival (OS), toxicity profile. Exploratory objectives include the use of plasma specimens and cerebrospinal fluid (if possible) to detect biomarkers predicting the efficacy of anlotinib.

Condition Glioma, Gliomas, Gliomas, glial tumor, Malignant Brain Stem Tumor
Treatment Anlotinib
Clinical Study IdentifierNCT04668508
SponsorZhejiang Cancer Hospital
Last Modified on1 February 2023

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