Lung Ultrasound Artefact Analysis for Exclusion of Acute Rejection in Lung Transplant Recipients

  • End date
    Dec 1, 2023
  • participants needed
  • sponsor
    Mayo Clinic
Updated on 5 July 2022
Accepts healthy volunteers


This study is being done to study a safe and non-invasive way to diagnose lung rejection and infection.


Lung transplant recipients are at high risk for lung rejection and lung infection after transplant. This is diagnosed by performing lung bronchoscopies and lung biopsies. These procedures carry an increased risk for complications and are costly. This study is being done to study a safe and non-invasive way to diagnose lung rejection and infection.

Condition Post-Lung Transplantation Bronchiectasis
Treatment Lung ultrasound
Clinical Study IdentifierNCT04582279
SponsorMayo Clinic
Last Modified on5 July 2022


Yes No Not Sure

Inclusion Criteria

Adult patients (> 18 yrs) who had undergone single/double/heart-lung transplant
Normal spirometry defined as a FEV1 without significant drop from baseline (significant drop = >10% decrease from baseline)
Clear chest radiograph over allograft

Exclusion Criteria

Patients who are unable to consent for the procedure
Patients with subcutaneous emphysema or other technical challenges that could interfere with satisfactory image acquisition- as deemed by the operator
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How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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