Nomogram to Predict Breast Cancer Related Lymphedema

  • STATUS
    Recruiting
  • End date
    Dec 31, 2027
  • participants needed
    600
  • sponsor
    Wuhan University
Updated on 27 January 2021

Summary

It has been hypothesized that damaged arm lymphatic drainage is associated with the arm lymphedema after axillary lymph node dissection (ALND). However, the majority of breast cancer patients with complete ALND has not suffered from arm lymphedema, which appears to be due to the residual arm lymph nodes that has not been removed in the axillary dissection. With the compensation of the residual arm lymph flow above the level of axillary vein, the arm lymphatic drainage could keep balance and remain normal function.

This arm lymphedema prediction model that included the protective factor, the proportion of arm lymph flow above the level of axillary vein, allows intraoperative intervention to be performed for the high-risk group. The arm lymphatics of these distinguished patients would be preserved to eliminate the occurrence of arm lymphedema in this study.

Details
Condition Lymphedema, Lymphedema, Breast Cancer, Breast Cancer, Breast Cancer Diagnosis, Breast Cancer Lymphedema, Axillary Lymph Node Dissection, breast carcinoma, cancer, breast, axillary dissection, axillary lymphadenectomy, Axillary Reverse Mapping
Treatment Axillary surgery based on lymphedema prediction nomogram
Clinical Study IdentifierNCT04665882
SponsorWuhan University
Last Modified on27 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients aged 18 years or older with T1-3 invasive breast cancer
Clinically node-positive breast cancer, defined as positive on preoperative axillary palpation, ultrasound examination, and computed tomography scan with contrast
Patients who underwent mastectomy with a positive sentinel lymph node (SLN)
Patients who underwent breast-conserving surgery containing more than two positive SLNs

Exclusion Criteria

Neoadjuvant chemotherapy
Previous history of breast cancer
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