HMG-CoA Reductase add-on in Chronic Kidney Disease Patients With Proteinuria

  • End date
    Dec 26, 2021
  • participants needed
  • sponsor
    Yuhan Corporation
Updated on 26 January 2021


This study is to evaluate the renal function of HMG-CoA reductase add-on in chronic kidney disease patients with proteinuria.

Condition chronic renal insufficiency, Chronic renal failure, Proteinuria, chronic kidney disease, chronic kidney disease (ckd)
Treatment Telmisartan 40mg, Telmisartan/Rosuvastatin 40/10mg
Clinical Study IdentifierNCT03550859
SponsorYuhan Corporation
Last Modified on26 January 2021


Yes No Not Sure

Inclusion Criteria

Aged 19 years
Chronic Kidney Disease (CKD) with CKD stage G2 or G3 and 300 mg/g urine PCR 3000 mg/g
Diagnosed with hypertension
Written informed consent
Patients who have not administered statin (including rosuvastatin) and hyperlipidemia treatment for at least 4 weeks prior to randomization

Exclusion Criteria

Type I diabetes
Uncontrolled diabetic patients with HbA1c > 10% at screening
Hypertensive patients whose mean blood pressure was not controlled at 160/90 mmHg or more in triplicate despite the use of antihypertensive agents at the time of randomization
Calculated LDL-C 160 mg/dL at randomization
Patients who have taken RAS blockers (ACE inhibitor, ARB, and Aldosterone antagonist) for 4 weeks prior to randomization
Heart failure patients with NYHA class IV
Patients with acute and chronic liver disease, acute inflammation, hematologic abnormalities and cancer within the last 6 months
Patients with a history of cerebral blood cardiovascular complications (cerebral infarction, transient ischemic attack, myocardial infarction, unstable angina, coronary artery bypass, and percutaneous coronary intervention)
Patients taking immunosuppressive drugs
Patients undergoing eGFR <30 mL/min/1.73 m2 (CKD-EPI formula) or renal replacement therapy (dialysis or renal transplant) at screening
Patients with a change in eGFR (CKD-EPI formula) value showing a difference of more than 30% in the last 6 months at screening
Creatine kinase (CK) level 3x ULN (upper limit of normal range)
Patients who are pregnant or planning to become pregnant
Contraindications stated in the SPC of telmisartan or rosuvastatin
Those participating in other clinical trials for investigational products at screening
Patients deemed to be ineligible to participate in the trial by investigator
Clear my responses

How to participate?

Step 1 Connect with a site
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Preferred Language
Other Language
Please verify that you are not a bot.

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note