A Multicenter Clinical Study on the Safety and Efficacy of CAR-T in the Treatment of Relapsed / Refractory Non Hodgkin's Lymphoma

  • STATUS
    Recruiting
  • End date
    Oct 21, 2025
  • participants needed
    200
  • sponsor
    Hebei Senlang Biotechnology Inc., Ltd.
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Updated on 27 January 2021
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Summary

This study is a multicenter, non randomized, single arm, open clinical trial. The selected disease was relapsed / refractory NHL, and the disease was classified into highly aggressive lymphoma, invasive lymphoma and inert lymphoma; Highly invasive NHL included Burkitt lymphoma (BL), lymphoblastic lymphoma (LBL), high-grade B-cell lymphoma, etc; Invasive NHL includes diffuse large B-cell lymphoma, mantle cell lymphoma and peripheral T-cell lymphoma; Inert NHL contains follicular lymphoma, small lymphocytic lymphoma and marginal zone lymphoma.

Description

A single car consists of scFv, hinge region, transmembrane region, costimulatory domain and zeta subunit of CD3.Prior to CAR-T cell infusion, the patients will be subjected to preconditioning treatment. After CAR-T cell infusion, the patients will be evaluated for adverse reactions and efficacy.

Details
Condition Lymphoma, Non-Hodgkin's Lymphoma, Lymphoma, Non-Hodgkin's Lymphoma, non-hodgkin's lymphoma (nhl)
Treatment leukapheresis, Auto CAR-T, Cyclophosphamide,Fludarabine
Clinical Study IdentifierNCT04666168
SponsorHebei Senlang Biotechnology Inc., Ltd.
Last Modified on27 January 2021

Eligibility

 Yes No Not Sure

Inclusion Criteria

Fully understand and voluntarily sign the informed consent form, and be
willing and able to comply with the visit, treatment plan, laboratory
examination and other requirements of the study specified in the test flow
sheet; 2. Patients with hematopoiesis and lymphoid tissue tumors diagnosed as
relapsed and refractory by clinical diagnosis were defined as relapse or
refractory
Primary drug resistance to standard treatment regimen
Or PD occurred after at least second-line standard treatment
Or the last treatment effect was SD and lasted no more than 6 months
Or CD20 positive patients were ineffective or relapsed after anti-CD20 mAb treatment
Or PD after autologous hematopoietic stem cell transplantation, or recurrence confirmed by biopsy within 12 months, or salvage treatment after autologous hematopoietic stem cell transplantation has no remission or recurrence after treatment
According to RECIST version 1.1 , there should be at least one measurable tumor focus; 4. Subjects with ECoG score of 0-2 5. 14 years old age 75 years old, both male and female; 6. The tumor cells were positive for CD19 or CD22 / CD30 / CD7 / CD79 by immunohistochemistry or flow cytometry; 7. The expected survival time is more than 3 months from the date of signing the informed consent 8. Laboratory examinations meet the following conditions: hemoglobin 80g/L, platelet count 50 10^9/L, absolute neutrophil count (ANC) 1.0 10^9/L, if the investigator believes that the above inspection value is below the lower limit It is caused by tumor invading bone marrow and can be included in the group after consultation with the sponsor; 9. The main organ function indicators meet the following conditions: AST (aspartate aminotransferase)/ALT (alanine aminotransferase)/ALP (alkaline phosphatase) 2.5 ULN, serum creatinine 1.5 ULN, total bilirubin 1.5 ULN, left Ventricular ejection fraction (LVEF) 50%, and minimum pulmonary function reserve (dyspnea is not higher than level 1 and blood oxygen saturation> 92% under indoor conditions)

Exclusion Criteria

Severe cardiac insufficiency, left ventricular ejection fraction <50%
There is a history of severe lung dysfunction diseases
The patient has had other malignant tumors in the past 5 years, except for skin basal cell carcinoma, breast carcinoma in situ and cervical carcinoma in situ that have undergone radical treatment
Combined with severe or persistent infection and cannot be effectively controlled; Severe infection: Refers to sepsis or uncontrolled infection of the infected foci, and can be included in the group after infection is controlled
Combined metabolic diseases (except diabetes)
Combined with severe autoimmune disease or innate immune deficiency
Untreated active hepatitis (hepatitis B, defined as hepatitis B virus surface antigen [HBsAg] test results are positive, HBV-DNA 500 IU/ml and abnormal liver function; hepatitis C, defined as hepatitis C antibody [ HCV-Ab] positive, HCV-RNA higher than the detection limit of the analysis method and abnormal liver function) or combined with hepatitis B and C co-infection
Human immunodeficiency virus (HIV) infection or known acquired immunodeficiency syndrome (AIDS), or syphilis infection
A history of severe allergies to biological products (including antibiotics)
Participate in any other clinical drug trials at the same time within one month
There are other serious physical or mental illnesses or laboratory abnormalities that may increase the risk of participating in the research, or interfere with the results of the research, and patients who the researcher believes are not suitable for participating in this research
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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