Paracetamol / Ibuprofen for Postpartum Pain in the Early Postpartum Period

  • STATUS
    Recruiting
  • End date
    Nov 28, 2023
  • participants needed
    1000
  • sponsor
    Tel-Aviv Sourasky Medical Center
Updated on 27 January 2021
Investigator
shai ram, MD
Primary Contact
Tel Aviv Medical Center (9.7 mi away) Contact

Summary

The investigators will examine the effectiveness of non-opioid analgesia (Paracetamol versus Ibuprofen) in the early postpartum period

Description

Postpartum pain is a common problem that leads to difficulties in basic daily activities, overuse of opioid medications, and even impaired breastfeeding ability. Non-opioid analgesia may play an essential role in reducing pain and improving the postpartum period including the ability to breastfeed and caring for the newborn.

This study will compare non-opioid treatment - 1000 mg Paracetamol versus 400 mg Ibuprofen in order to determine the optimal pain relief treatment in the early postpartum period that may decrease the use of opioid analgesia.

The investigators will evaluate the pain by the Numerical Rating Scale (NRS) index in the early postpartum period. The evaluation will conduct at 4-time points - while the women taking the pain relief (time 0), an hour later (time 1), 4, and 6 hours later (time 4 and time 6).

The investigators will compare the analgetic effect of each drug and evaluate the need for additional analgesia whether opioid or not.

Furthermore, the investigators will examine when women sought pain relief and whether pain relief contributes to the ability of Breastfeeding.

Details
Condition Pain, Acute Pain Service, Post-Surgical Pain, Pain (Pediatric), ache
Treatment Ibuprofen 400 mg, Paracetamol 1000 mg
Clinical Study IdentifierNCT04653506
SponsorTel-Aviv Sourasky Medical Center
Last Modified on27 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Women between the ages of 18-50, who gave birth in a vaginal birth

Exclusion Criteria

Sensitivity to Paracetamol or Ibuprofen
After cesarean section
Received analgesia prior to study recruitment
Perineal tears grade 3 \ 4
Women with chronic pain, rheumatic disease, fibromyalgia, or trauma
Women with a diagnosis or medication for anxiety or depression
Dropout for women whose newborns needed respiratory support with intubation, cooling, prolonged hospitalization in NICU exceeding one week
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