NeuroCognitive Bases of Tool Use

  • End date
    Feb 7, 2024
  • participants needed
  • sponsor
    Hospices Civils de Lyon
Updated on 7 August 2021


Tool use is considered to be the hallmark of complex cognitive adaptations that humans have achieved trough evolution, that provides an adaptive advantage to the human species. Even if nonhuman species do use tools too, human tool use is much more complex and sophisticated. If humans have special abilities for tool use, it has to be grounded in a specific neuroanatomical substrate. Humans and nonhumans share a similar prehension system located within the superior parietal lobe and the intraparietal sulcus. However, there is a human specificity: the supramarginal gyrus within the left inferior parietal lobe is unique to humans, and could play a central role in tool use. This project aims to study the neurocognitive bases of human tool use with functional Magnetic Resonance Imaging (fMRI), to precise the cognitive mechanisms through which humans are able to use tools.

Condition healthy
Treatment fRMI
Clinical Study IdentifierNCT04566744
SponsorHospices Civils de Lyon
Last Modified on7 August 2021


Yes No Not Sure

Inclusion Criteria

To be between the ages of 18 and 65 years old
Having given an informed consent for the study

Exclusion Criteria

Pregnant or breastfeeding woman
Persons under curators or deprived of civil rights or deprived of their freedom
Not being registered with the French Social Security System
Not able to read/write the French
Neurologic or psychiatric illness, known or revealed during the inclusion visit
Substance intake ( taking psychoactive medications or recreational drugs) on the day of the experiment
Noise intolerance
Unable to fill a questionnaire (severe cognitive troubles)
Not willing that their personal doctor to be informed in case of a MRI anomaly
Not willing to be informed in case of MRI anomaly
Subjects must not have metallic or electronic implants in the body : pacemakers or pacemaker wires, open heart surgery, artificial heart valve, brain aneurysm surgery, middle ear implant, hearing aid, braces or extensive dental work, cataract surgery or lens implant, implanted mechanical or electrical device, or artificial limb or joint o foreign metallic objects in the body (bullets, pellets, shrapnel, or metalwork fragments) or current or past employment as machinists, welders or metal workers, tattoos near the head or neck regions, permanent makeup
Not willing to complete the study
Appearance of a exclusion criterion during the protocol
Appearance of an undesirable event preventing the completion of the protocol
Too great head movements (>4mm for the session)
Detection of artifacts in the brain images collected
Clear my responses

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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