Last updated on March 2017

The Genetics of Polycystic Ovarian Syndrome


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Polycystic ovary syndrome
  • Age: Between 18 - 100 Years
  • Gender: Female
  • Other:
    amenorrhea (<9 menses/yr); 3) clinical and/or biochemical evidence of
    hyperandrogenemia; 4) normal TSH and prolactin <25 ng/mL; 5) on no hormonal or
    insulin sensitizing medication for at least 3 months and have not taken Provera for
    at least ten days prior to enrollment. If the subject has previously had hormone
    levels drawn and processed in the Reproductive Endocrine Laboratory, it is not
    necessary to discontinue hormonal or insulin sensitizing medication.
    A second group of PCOS probands with a documented diagnosis of PCOS will also be
    recruited. These subjects will meet all of the criteria above except that they will be on
    hormonal medication.
    menstrual cycles 21-35 days or history of regular menstrual cycles in the past if
    menopausal; 3) no clinical or biochemical evidence of hyperandrogenism; 4) normal TSH and
    prolactin <25 ng/mL; 5) on no hormonal or insulin sensitizing medication for at least 3
    months.
    <25 ng/mL; 5) on no hormonal or insulin sensitizing medication for at least 3 months.
    for the female unaffected relatives. In Iceland, control subjects will be recruited from
    the Icelandic national registry, matched by age and sex to PCOS subjects and their family
    members. They will otherwise be recruited at random. In Boston, control subjects will be
    recruited from email and newspaper listings.

You may not be eligible for this study if the following are true:

  • adrenal hyperplasia as defined by a fasting 17OH progesterone level <200 ng/mL or a
    cortrosyn stimulated 17 OH progesterone level <500 ng/mL.
    None. Exclusion Criteria-Control Subjects: Control subjects chosen at random will be
    excluded if they are already participating in the study as a PCOS subject or are a first
    degree family member of the PCOS subject.

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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