Statin Therapy to Reduce Progression in Women With Platinum Sensitive Ovarian Cancer
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- STATUS
- Recruiting
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- End date
- Jan 12, 2024
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- participants needed
- 20
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- sponsor
- Bobbie Jo Rimel, MD
Summary
This is a single arm pilot trial to evaluate the feasibility of using a simvastatin intervention, and to evaluate its effects on cancer progression, among 20 patients with platinum-sensitive ovarian cancer, treated with carboplatin and liposomal doxorubicin at Cedars-Sinai Medical Center.
Description
This is a pilot study of statin therapy to examine the feasibility of simvastatin use to reduce disease progression in 20 patients with platinum-sensitive ovarian cancer at Cedars-Sinai Medical Center. This study will focus on patients with recurrent platinum sensitive ovarian cancer to increase the likelihood that this population will experience recurrent disease during the 6-month intervention and follow-up. In addition, this population of patients has a narrow range of standard of care carboplatin doublet combinations that are prescribed, enabling the investigators to create a more homogenous study population. Given their high risk of developing recurrent disease, women with platinum sensitive ovarian cancer, have the potential to derive the maximum benefit from an intervention that could delay disease progression and enhance survival.
Details
| Condition | Recurrent Ovarian Cancer, Platinum-sensitive Ovarian Cancer |
|---|---|
| Treatment | simvastatin 40mg |
| Clinical Study Identifier | NCT04457089 |
| Sponsor | Bobbie Jo Rimel, MD |
| Last Modified on | 12 May 2022 |
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