Hemodynamic Changes in the Aorta After Endovascular Treatment of the Aortic Dissection

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  • sponsor
    Hospices Civils de Lyon
Updated on 27 January 2021


Aortic dissection (AD) is a serious pathology affecting one person for 300 000 habitants per year. In case of complicated AD on the descending aorta, it is necessary to perform an endovascular surgery in association with medical treatment. An endoprosthesis is implanted on the descending thoracic aorta in order to close the main intimal tear. This closure lead to an increase in the thoracic true lumen diameter, a decrease in the thoracic false lumen diameter, a better perfusion of the aortic branches. Furthermore, even in case of open surgical treatment of the ascending aorta it can be necessary to perform an endovascular treatment on the descending aorta, either to prevent and treat aneurysmal evolution or to treat patent malperfusion syndrome.

CT and Magnetic Resonance angiography, by the realization of an aortic morphologic evaluation, are the two key imaging exams in the DA. Nevertheless, CT can't provide aortic dynamic evaluation, contrary to MRI. This exam, thanks to the phase-contrast sequence can measure velocity and flow data in vessels, including aorta but also true and false lumen in the AD. Thus, by verifying the perfusion of the aortic true lumen and the aortic branches it is possible to perform an early evaluation of the endovascular treatment of the DA.

Actually, only one study has realized an aortic dynamic evaluation on the AD, unfortunately this study was limited to non-operated patients.

In order to assess the place of MRI in the AD, the ingestigation propose to determine if phase-contrast MRI is able to evaluate the impact of the endovascular treatment on the hemodynamic state of the aorta and its branches.

Condition Aneurysm, Aortic Dissection
Treatment magnetic resonance imaging
Clinical Study IdentifierNCT03669055
SponsorHospices Civils de Lyon
Last Modified on27 January 2021


Yes No Not Sure

Inclusion Criteria

Patients with an aortic dissection requiring endovascular treatment
The endovascular treatment will be indicated according to the guidelines after medical, radiological and surgical multidisciplinary discussion in our hospital
Patients that have signed the informed consent form
Members of a social protection scheme

Exclusion Criteria

Patients with an aortic dissection requiring an emergency intervention
Patients with a contra-indication to endovascular treatment
Contra-indication to MRI: claustrophobia, ferromagnetic materials: pacemaker, prosthetic heart valve, implantable cardioverter defibrillators, vascular clip
Patients under guardianship
Patients with difficulty in understanding the French language
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