Response of Preterm Infants to Multisensory Stimuli

  • STATUS
    Recruiting
  • End date
    Sep 26, 2023
  • participants needed
    84
  • sponsor
    University Hospital, Geneva
Updated on 26 January 2021

Summary

The aim of this study is to measure the variation of oxytocin and cortisol levels in the saliva of premature neonates and their mother after sensorial stimuli.

Description

The aim of this study is to measure the variation of oxytocin and cortisol levels in the saliva of neonates with gestational age ranging from 32 to 34 completed weeks and in the saliva of their mothers. The measurements are taken before and after sensorial stimuli including mother voice exposure +/- tactile distraction for 10 minutes. The two interventions are performed between day 5 and day 12 after birth and 24 to 48 hours apart. Each child is randomised in a group depending on order of the two interventions.

Investigators hypothesize that an increase in the oxytocin/cortisol ratio will be occurred in neonates after hearing their mothers and that simultaneous tactile stimulation will mitigate that effect.

Concomitantly, the neonate's vital signs and his facial expressions are recorded during interventions. The mothers anxiety level is assessed PSS-NICU questionnaire given before the first and after the second intervention.

Details
Condition Mother-Infant Interaction, Mother-Infant Interaction, Mother-Infant Interaction
Treatment Voice alone, Voice + tactile stimuli
Clinical Study IdentifierNCT04665440
SponsorUniversity Hospital, Geneva
Last Modified on26 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Newborn gestational age 32 0/7 weeks to 34 6/7 weeks
Born at university hospital Geneva
French speaking parents
Out of incubator
Signed consent

Exclusion Criteria

Newborn with one of the above conditions
Congenital malformation
intraventricular hemorrhage grade III or IV
white matter abnormality
anti-epileptic or sedative drugs
altered consciousness level
Infant requiring respiratory support
psychiatric disorders in the mother or antenatal use of psychoactive drugs
Bilateral absent otoacoustic emissions and/or auditory evoked potential
Parents refusal to participate
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