Effects of Curcumin Supplementation in Patients With Chronic Kidney Disease on Peritoneal Dialysis

  • STATUS
    Recruiting
  • days left to enroll
    87
  • participants needed
    30
  • sponsor
    Universidade Federal Fluminense
Updated on 26 January 2021

Summary

The objective of this study is to assess whether supplementation with curcumin could modulate the intestinal microbiota, reducing levels of inflammatory markers of oxidative stress, uremic toxins and inflammasome, in patients with chronic kidney disease in peritoneal dialysis.

Description

Curcumin is a chemical compound of the curcuminoids class found in the root of Curcuma (Curcuma longa), and due to its potential antioxidant and anti-inflammatory, has been suggested as a nutritional strategy to reduce oxidative stress and inflammation present in several chronic diseases. Although it is a promising therapy, there are no studies evaluating the effects of curcumin in patients with chronic kidney disease (CKD) in peritoneal dialysis (PD). The aim of this study is to evaluate the effect of curcumin supplementation on inflammatory markers and oxidative stress in patients with CKD in PD. Methods: This is a longitudinal randomized clinical double-blind crossover study, with a washout period and placebo-controlled, where patients will be randomized into two groups: Turmeric and Placebo. After the 12-week supplementation period, a washout (12 weeks) will be performed for subsequent crossover of the patients. Mononuclear cells will be extracted from whole blood and the expression of m ribonucleic acid from transcription factors (Nrf2 and NF-kB), antioxidant enzymes (NQO1, HO-1), as well as NLRP3 inflammasome will be analyzed by real-time Polymerase Chain Reaction and protein expression by western blotting. Inflammatory cytokine levels will be assessed by ELISA, also, plasma levels of TBARS, routine laboratory parameters, as well as food intake and nutritional status.

Details
Condition Renal Failure, Peritoneal Dialysis, Hemodialysis, Chronic Kidney Diseases, Kidney Failure (Pediatric), Kidney Failure, chronic kidney disease, chronic kidney disease (ckd)
Treatment Curcumin Supplementation
Clinical Study IdentifierNCT04413266
SponsorUniversidade Federal Fluminense
Last Modified on26 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Clinical diagnosis of Chronic Kidney Disease
Peritoneal dialysis patients for more than 6 months
Aged from 18 to 60 years
Must be able to swallow tablets

Exclusion Criteria

Patients pregnant
Smokers
Using antibiotics in the last 3 months
Using antioxidant supplements in the last 3 months
Usual intake of turmeric
Usual intake Autoimmune
Clinical diagnosis of infectious diseases
Clinical diagnosis of Cancer
Clinical diagnosis of AIDS
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