Efficacy and Safety of MEDI6570 in Patients With a History of Myocardial Infarction (GOLDILOX)

  • STATUS
    Recruiting
  • End date
    Aug 22, 2023
  • participants needed
    400
  • sponsor
    AstraZeneca
Updated on 23 July 2022
myocardial infarction
infarct

Summary

A Phase IIB Parallel group Study to Evaluate the Efficacy and Safety of MEDI6570 in Participants with a Prior Myocardial Infarction.

Description

This Phase IIB, proof-of-concept, dose-range finding clinical study is being conducted to evaluate the anti-inflammatory potential of MEDI6570 and its effect on surrogates for atherosclerotic and heart failure (HF) events in patients with a history of myocardial infarction (MI). The results of the Phase IIB study will inform future clinical development options and precision medicine strategy for future clinical studies.

Participants will be randomized in a 2:2:1:1 ratio after protocol Amend 2, 360 evaluable participants (111 evaluable participants in each of the 2 MEDI6570 groups, plus 27 evaluable participants in the legacy low dose MEDI6570 group, plus 111 participants in pooled placebo) will complete the study.

Details
Condition Coronary Heart Disease (CHD)
Treatment Placebo, MEDI6570
Clinical Study IdentifierNCT04610892
SponsorAstraZeneca
Last Modified on23 July 2022

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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