Integrated Care of Co-morbidities vs Standard Care After AHRF in the Intensive Care Unit

  • End date
    May 31, 2023
  • participants needed
  • sponsor
    Dan Adler
Updated on 28 January 2021


The study will assess the potential benefit of implementing a complex bundle of interventions to treat important - often unrecognized - comorbidities in patients surviving an episode of Acute Hypercapnic Respiratory Failure (AHRF). This study will also provide a comparative analysis of the costs and health consequences of two alternative strategies to inform decision making about healthcare. All interventions are individually evidence-based and seem sound to hypothesize that implementing such interventions might improve patient's outcome and reduce the financial burder of repeated hospitalization in AHRF survivors.

Condition Acute Hypercapnic Respiratory Failure
Treatment Bundle of comorbidities care
Clinical Study IdentifierNCT04650412
SponsorDan Adler
Last Modified on28 January 2021


Yes No Not Sure

Inclusion Criteria

Consent form signed
Acute hypercapnic respiratory failure defined as PaCO2 > 6.3 kPa requiring invasive or non-invasive mechanical ventilation in the ICU

Exclusion Criteria

Age < 18 years old
Known or suspected neuromuscular diseases
Iatrogenic respiratory failure (i.e. drug overdose, AHRF after starting opiates or increasing opiates dose)
Life expectancy < 3 months
Confusion or major psychiatric illness
Patient unable to be weaned from NIV
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