Inflammatory Profiling in Chronic Lung Disease

  • STATUS
    Recruiting
  • End date
    Jun 30, 2024
  • participants needed
    60
  • sponsor
    Ludwig Boltzmann Institute for Lung Vascular Research
Updated on 27 January 2021

Summary

The aim of this study is to investigate the underlying inflammatory profile in patients with chronic lung disease and determine the association pulmonary hypertension.

Description

Chronic lung diseases (CLD), such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are often complicated by the presence of pulmonary hypertension (PH), where even a mild elevation of blood pressure in the pulmonary arteries is associated with an even poorer prognosis. In this study, we will investigate whether similarities exist in the inflammatory profile that could potentially underlie all forms of pulmonary hypertension. Inflammatory data will be generated using flow cytometry, expression profiling and histological analysis and compared to the associated clinical data.

Details
Condition Pulmonary Hypertension, Effects of Chemotherapy, Anemic Cancer, Habit Reversal, Surviving Abuse, Abdominal Surgery, Primary Insulin Hypersecretion, Open Heart Surgery, Cancer Prevention, Stasis Dermatitis, Nerve Injury, Pseudobulbar Affect, Joint Injuries, Chronic Pelvic Pain, Pelvic Adhesions, Mental Disability, Dental Filling, Low Testosterone, Myopic Macular Degeneration, Spinocerebellar Disorders, Complicated Grief, Serial Evaluation of Ductal Epithelium, Renal Anemia, Chronic Renal Anemia, Recurrent Pregnancy Loss, Testotoxikose, Functional Dyspepsia, Pulmonary Arterial Hypertension, Infantile Fibrosarcoma, Severe Premenstrual Symptom, Partial Medial Meniscectomy, Memory Problems, Gambling Problems, Cancer Treatment, Indikation: Diabetes - Typ II, Spine Athroplasty, Catheter Complications, Late Infantile Neuronal Ceroid Lipfuscinsosis, Cancer Prevention, Surviving Abuse, Joint Injuries, Abdominal Surgery, Mental Disability, Pelvic Adhesions, Low Testosterone, Dental Filling, Habit Reversal, Complicated Grief, Chronic Pelvic Pain, Gambling Problems, Myopic Macular Degeneration, Nerve Injury, Severe Premenstrual Symptom, Stasis Dermatitis, Pulmonary Arterial Hypertension, Open Heart Surgery, Recurrent Pregnancy Loss, Effects of Chemotherapy, Renal Anemia, Functional Dyspepsia, Catheter Complications, Serial Evaluation of Ductal Epithelium, Chronic Renal Anemia, Cancer Treatment, Anemic Cancer, Spinocerebellar Disorders, Pseudobulbar Affect, Spine Athroplasty, Indikation: Diabetes - Typ II, Partial Medial Meniscectomy, Primary Insulin Hypersecretion, Testotoxikose, Infantile Fibrosarcoma, Late Infantile Neuronal Ceroid Lipfuscinsosis, Memory Problems
Treatment Tissue sampling
Clinical Study IdentifierNCT04654767
SponsorLudwig Boltzmann Institute for Lung Vascular Research
Last Modified on27 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients undergoing lung transplant with COPD or IPF, with associated PH
Signed informed consent

Exclusion Criteria

patients without written informed consent
Signs of any infection such as pneumonia, pulmonary tuberculosis or infections with pleural effusions
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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