SMA Targeted Magnetic Stimulation Against Auditory Verbal Hallucinations (SMA-AVH)

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    Uppsala University
Updated on 27 May 2022
Accepts healthy volunteers


Auditory verbal hallucinations (AVH) are prevalent among patients with psychiatric disorders. Not only being highly stressful and functionally impairing, AVH often persist despite treatment. Recent attempts to treat AVH with add-on repetitive transcranial magnetic stimulation (rTMS) when targeting the temporoparietal junction (TPJ), a language node in the brain, has gained limited success. The aim of this investigation is to reduce AVH with rTMS using continous theta-burst stimulation over a novel target, the supplementary motor area (SMA), in participants with frequent AVH, while also assessing potential neurophysiological mechanisms underlying the symptom.

Condition Auditory Hallucination
Treatment continuous theta burst stimulation over the SMA, sham continuous theta burst stimulation over the SMA
Clinical Study IdentifierNCT04651621
SponsorUppsala University
Last Modified on27 May 2022


Yes No Not Sure

Inclusion Criteria

Inclusion criteria for the AVH group
Reported AVH with a minimum frequency of at least daily occurrence, with onset more than one month ago
Stable psychopharmacological treatment past month
Inclusion criteria for the non-AVH control group
Reporting no occurrences of AVH for the past year
Stable psychopharmacological treatment past month
Inclusion criteria for the healthy control group
No life-time occurrence of AVH
No history of psychiatric disorders as assessed with a Mini-International Neuropsychiatric Interview (M.I.N.I.)

Exclusion Criteria

Ferromagnetic or electromagnetic implants that may pose a risk during magnetic resonance imaging (MRI) and/or cTBS
A history of epilepsy
Current substance use disorder or a history of alcohol use disorder as assessed with Alcohol Use Disorders Identification Test (AUDIT), Drug Use Disorders Identification Test (DUDIT), urine samples with test for illicit drugs and Phosphatidylethanol (PEth)
Daily benzodiazepine use
Factors that make the participant unlikely to be able to complete the study
Clear my responses

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