Effects of Oral Cancer Treatments on Upper Esophageal Opening During Swallowing

  • End date
    Dec 27, 2023
  • participants needed
  • sponsor
    University of Wisconsin, Madison
Updated on 27 June 2022
oral cancer


The purpose of this study is to investigate post-operative and post-radiation upper esophageal sphincter opening measures in oral cancer patients, compare measures to age- and gender-matched healthy adults, and determine relationships with patient swallowing outcomes and quality of life.

Condition Cancer of Head and Neck
Treatment Videofluoroscopic imaging (VFSS) with high-resolution manometry (HRM)
Clinical Study IdentifierNCT04658342
SponsorUniversity of Wisconsin, Madison
Last Modified on27 June 2022


Yes No Not Sure

Inclusion Criteria

Oral cancer that includes tongue or floor of mouth clinical stage T1 or higher
May have disease that extends to base of tongue or other site as long as floor of mouth or tongue are involved
Adults at least 18 years of age

Exclusion Criteria

Oral cancer of the lip, cheek, palate or other site not impacting tongue or floor of mouth musculature
History of floor of mouth, tongue base, pharyngeal or laryngeal surgical resection
History of radiation treatment to the head and neck
History of dysphagia prior to onset of oral cancer symptoms
Allergy to lidocaine, barium, adhesive tape or apple flavoring
Woman of childbearing years who are pregnant
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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