High Definition Transcranial Direct Current Stimulation (HD-tDCS) in Patients With Mild Cognitive Impairment

  • STATUS
    Recruiting
  • End date
    Aug 31, 2022
  • participants needed
    60
  • sponsor
    Kaohsiung Veterans General Hospital.
Updated on 5 February 2021

Summary

The study aimed to investigate whether high definition transcranial direct current stimulation (HD-tDCS) could benefit global cognitive function and sub-domains of cognition (visual/verbal/working memory, executive function, attention, processing speed, language, and frontal lobe function), mood (depression and anxiety), and subjective memory impairment in patients with mild cognitive impairment.

Description

Transcranial direct current stimulation (tDCS), a novel, non-invasive and safe neuro-modulating technique, has been developed as a new therapeutic option for neuropsychiatric disorders. It encompasses the induction of a relatively weak constant current flow through the cerebral cortex via scalp electrodes. Dependent on stimulation polarity, this results in a modulation of cortical excitability and spontaneous neural activity. Compared with tDCS, high-definition transcranial direct current stimulation (HD-tDCS) is highly focal and can specifically modulate cortical activity within the region confined by its 4 x 1 ring of elctrodes, such that the targeted region becomes more amenable to neuroplastic change. Studies have suggested that tDCS improve cognition, including memory recall, verbal fluency and executive function. Yet, there is not HD-tDCS study on MCI. The purpose of this study is to examine whether HD-tDCS could benefit global cognitive function and sub-domains of cognition (visual/verbal/working memory, executive function, attention, processing speed, language, and frontal lobe function), mood (depression and anxiety), and subjective memory impairment in patients with mild cognitive impairment.

Details
Condition Mild Cognitive Impairment, Mild Neurocognitive Disorder
Treatment HD-tDCS treatment, sham (placebo) HD-tDCS
Clinical Study IdentifierNCT04121156
SponsorKaohsiung Veterans General Hospital.
Last Modified on5 February 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age between 65 yrs and 85 yrs?
Gender: Male or Female
Do you have any of these conditions: Mild Neurocognitive Disorder or Mild Cognitive Impairment?
Aged 65 to 85 years
mild cognitive impairment
right handed

Exclusion Criteria

Having epilepsy, severe physical illness, any current psychiatric comorbidity or history of substance dependence
Having contraindications for transcranial electrical/magnetic stimulation
Having intracranial metal foreign bodies
Having a history of intracranial neoplasms or surgery, or a history of severe head injuries or cerebrovascular diseases
Receiving psychotropic agents such as antipsychotic, antidepressant, benzodiazepam and anxiolytics etc
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