Safety and Efficacy of KRT-232 in Combination With Acalabrutinib in Subjects With R/R DLBCL or R/R CLL

  • STATUS
    Recruiting
  • End date
    Mar 9, 2024
  • participants needed
    84
  • sponsor
    Kartos Therapeutics, Inc.
Updated on 9 August 2022
lymphoma
leukemia
diffuse large b-cell lymphoma
b-cell lymphoma
large b-cell lymphoma
btk inhibitor
acalabrutinib

Summary

This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, combined with acalabrutinib for the treatment of adults with Diffuse Large B-Cell Lymphoma and Chronic Lymphocytic Leukemia. Participants must be relapsed/refractory (having failed prior therapy)

Details
Condition Diffuse Large B Cell Lymphoma, Chronic Lymphocytic Leukemia, Non Hodgkin Lymphoma
Treatment acalabrutinib, KRT-232
Clinical Study IdentifierNCT04502394
SponsorKartos Therapeutics, Inc.
Last Modified on9 August 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Cohort 1: Confirmed diagnosis of TP53wt DLBCL (WHO); R/R DLBCL after at least 2 prior lines of treatment or 1 prior for patients who are ineligible for stem cell transplant
Cohort 2: Confirmed diagnosis of TP53wt CLL (iwCLL); R/R CLL after at least 1 prior line of treatment
ECOG 0 to 2
Adequate hematologic, hepatic, and renal functions

Exclusion Criteria

Prior treatment with any MDM2 inhibitor
Prior treatment with any BTK inhibitor
Clear my responses

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