Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic Hypogonadism

  • End date
    Feb 28, 2025
  • participants needed
  • sponsor
    Stephanie B. Seminara, MD
Updated on 4 October 2022
klinefelter syndrome
secondary hypogonadism


The goal of this study is to develop novel treatments for patients with a condition called hypogonadotropic hypogonadism (HH) through the use of exogenous kisspeptin.


  • Assignment: Each study subject will serve as their own control. The order of kisspeptin doses will be randomized within each set/exposure.
    • Delivery of Interventions:
    • Prior to the study visit, subjects will undergo a review of their medical history and screening laboratories. Subjects will also wear a gonadotropin releasing hormone (GnRH) pump prior to the inpatient study visit.
    • On the day of the inpatient study, the subjects will
    • Undergo q10 min blood sampling for 6 hours,
    • Receive kisspeptin intravenous (IV) boluses from hour 6 to hour 44 (20 boluses total),
    • Undergo q10 min blood samplings for another 6 hours,
    • Receive a single GnRH IV bolus at hour 51.

Condition Hypogonadotropic Hypogonadism
Treatment kisspeptin 112-121, GnRH
Clinical Study IdentifierNCT04648969
SponsorStephanie B. Seminara, MD
Last Modified on4 October 2022


How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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