RESting-state Functional MRI for Prediction of Post-surgical Prognosis In Pediatric Drug-Resistant Epilepsy (RESPIRE)

  • End date
    Apr 19, 2026
  • participants needed
  • sponsor
    Fondation Ophtalmologique Adolphe de Rothschild
Updated on 4 October 2022


Resting-state functional MRI (r-fMRI) has emerged in recent years to analyze resting networks. It allows, without active participation of the patients, to identify and analyze the different functional brain networks. The analysis of r-fMRI can be done thanks to the graph theory, which is based on the based on the calculation of quantifiable parameters applied to the functional network studied, making it possible to assess its effectiveness.

To the knowledge of the investigators, no study has used graph theory applied to r-fMRI data in order to obtain parameters useful for the useful parameters for the individual prognosis of children who have to be operation for drug-resistant lesional epilepsy.

Condition Epilepsy
Treatment séquence resting state
Clinical Study IdentifierNCT04451278
SponsorFondation Ophtalmologique Adolphe de Rothschild
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

Patient aged between 6 and 18 years
Receiving an MRI for lesional drug-resistant epilepsy
Affiliated or beneficiary of a social security plan
Whose parents or guardians have received information about the study and have given their express consent to participate in the study

Exclusion Criteria

Contraindication to absolute or relative MRI (in particular, pregnant or breastfeeding women)
History of intracranial surgery
MRI performed under general anesthesia
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