Micro-Ultrasound for the Detection and Localization of Prostate Cancer Tumors in Patients Undergoing Radical Prostatectomy

    Not Recruiting
  • End date
    Sep 1, 2023
  • participants needed
  • sponsor
    Jonsson Comprehensive Cancer Center
Updated on 20 October 2022


This trial studies the ability of micro-ultrasound to detect and characterize prostate cancer tumors in patients undergoing radical prostatectomy (removal of the entire prostate and some of the tissue around it). Usually multiparametric magnetic resonance imaging is used for the detection and targeted therapy of prostate cancer, but its accuracy remains imperfect. Micro-ultrasound may be superior as it provides real-time tumor visualization which may simplify and improve prostate cancer targeted therapy. This may also reduce the need for and substantial costs of radical prostatectomy.



I. Determine if micro-ultrasound (US) can be used to identify prostate cancer foci with equivalent (non-inferior) performance relative to multiparametric magnetic resonance imaging (mpMRI).


I. Determine if micro-US can be used to contour prostate cancer foci with equivalent (non-inferior) accuracy to mpMRI.


I. Determine if ex vivo micro-US images have quality comparable to in vivo micro-US images.


I. Determine if micro-US can be used to evaluate suspicion of extracapsular extension (ECE) with equivalent (non-inferior) accuracy to mpMRI.


Patients may undergo transrectal micro-ultrasound scan (TRUS) prior to standard-of-care radical prostatectomy. Following radical prostatectomy, removed glands are scanned and micro-US, standard of care mpMRI, and whole mount images are analyzed and compared.

Condition prostate carcinoma, Prostate Cancer, Early, Recurrent, Prostate Cancer, Malignant neoplasm of prostate
Treatment Radical Prostatectomy, Transrectal Ultrasound, Digital Image Analysis
Clinical Study IdentifierNCT04299620
SponsorJonsson Comprehensive Cancer Center
Last Modified on20 October 2022

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