A Training Set for the HRD Model in EOC

  • End date
    Nov 26, 2022
  • participants needed
  • sponsor
    Lei Li
Updated on 27 January 2021


A homologous recombination deficiency (HRD) scoring model based on loss of heterozygosity (LOH) is little explored in epithelial ovarian cancer (EOC) patients. This study would recruit 200 Chinese EOC patients with known BRCA1/2 mutation status and resistance to platinum-based chemotherapy. A LOH-HRD model is to be constructed based on the genetic testing in these patients. The mutated genes, HRD score model and their relationship with the prognosis, would provide a full description of for the Chinese EOC patients, and a potential explanation of platinum-resistance in such population.

Condition Prognosis, Loss of Heterozygosity, Ovarian Epithelial Cancer, Epithelial Ovarian Cancer, Epithelial Ovarian Carcinoma, Homologous Recombination Deficiency, BRCA Mutation, ovarian epithelial carcinoma, carcinoma of the ovary, Platinum Resistance
Treatment Homologous recombination deficiency model
Clinical Study IdentifierNCT04651933
SponsorLei Li
Last Modified on27 January 2021


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