An Open-Label, Multicenter, Phase 1b/2 Study of the Safety and Efficacy of KRT-232 Combined With Ruxolitinib in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera MF (Post-PV-MF), Or Post-Essential Thrombocythemia MF (Post ET-MF) Who Have a Suboptimal Response to Ruxolitinib
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- STATUS
- Recruiting
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- End date
- Oct 30, 2024
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- participants needed
- 36
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- sponsor
- Kartos Therapeutics, Inc.
Summary
This is a phase 1b/2 study of KRT-232 combined with ruxolitinib in subjects with MF who have a suboptimal response after at least 18 weeks of treatment with ruxolitinib. The primary objective of the study is to determine a recommended phase 2 dose (RP2D) of KRT 232 in combination with ruxolitinib.
Details
| Condition | Myelofibrosis |
|---|---|
| Treatment | Ruxolitinib, KRT-232 |
| Clinical Study Identifier | NCT04485260 |
| Sponsor | Kartos Therapeutics, Inc. |
| Last Modified on | 30 May 2022 |
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