Epidural Spinal Cord Stimulation for Hypertension in Patients With Neuropathic Pain

  • End date
    Nov 1, 2024
  • participants needed
  • sponsor
    University of Kansas Medical Center
Updated on 3 February 2021


The purpose of the ESCAPE Study is to determine the extent to which epidural spinal cord stimulation (SCS) reduces arterial blood pressure (BP) in patients which chronic low back pain and hypertension. We also aim to determine the extent to which higher baseline BP (i.e., hypertension) predicts reductions in pain following SCS implant. This is an observational study of patients undergoing an implantation of a SCS device.


The broad research goal of this study is to examine the extent to which arterial blood pressure (BP) and blood markers related to hypertension and kidney function are reduced in a prospective cohort of patients undergoing implantation of an epidural spinal cord stimulator (SCS) for the purpose of managing chronic pain in the lower back and/or limbs.

Specific aims:

  1. Examine the extent to which BP (primary variable), norepinephrine (marker of sympathetic nerve activity in the blood), and a vascular ultrasound scan are improved following the implant of a SCS device among patients with chronic pain and hypertension.
  2. Examine the extent to which markers of kidney function in the blood [serum creatinine, glomerular filtration rate (GFR), and blood urea nitrogen (BUN)] are reduced following the implant of a SCS device among patients with chronic pain and hypertension.
  3. Determine the extent to which BP predicts reductions in pain following the implant of a SCS device.

Condition Vascular Diseases, Vascular Diseases, Hypertension, High Blood Pressure (Hypertension), High Blood Pressure (Hypertension - Pediatric), Diabetes and Hypertension, implanted electrodes, Pain, Post-Surgical Pain, Pain (Pediatric), Pain, Chronic Pain, Chronic Pain, Diabetes and Hypertension, High Blood Pressure (Hypertension), High Blood Pressure (Hypertension - Pediatric), Post-Surgical Pain, Pain (Pediatric), Elevated Blood Pressure, high blood pressure, arterial hypertension, chronic pains
Treatment Diagnostic tests
Clinical Study IdentifierNCT04598035
SponsorUniversity of Kansas Medical Center
Last Modified on3 February 2021


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