Eylea and Lucentis for Macular Edema in Branch Retinal Vein Occlusion

  • STATUS
    Recruiting
  • participants needed
    110
  • sponsor
    St. Erik Eye Hospital
Updated on 25 September 2022

Summary

Comparing time to recurrence of macular edema after an initial loading dose of at least three monthly anti VEGF injections (aflibercept or ranibizumab) for macular edema in BRVO.

Description

One hundred and ten patients with macular edema (ME) secondary to BRVO are randomized (1:1) to treatment with intravitreal injections of aflibercept or ranibizumab. An initial loading dose of at least three monthly injections is given in the study eye until the ME is resolved. Then patients are observed at regular intervals, initially every four weeks until study completion. Total follow-up time is nine months from baseline to completion. If ME recurs, patients are treated according to a treat-and-extend algorithm.

At every visit, visual acuity (VA) is measured with an ETDRS chart at 4 m. The fundus is examined by indirect ophthalmoscopy and by optical coherence tomography (OCT). Macular ischemia is evaluated with OCT angiography (OCT-A), visual field status with computerised perimetry and retinal sensitivity with microperimetry. Choroidal thickness is evaluated with enhanced depth imaging (EDI) OCT. Vision related quality of life (QoL) with NEI VFQ25.

Details
Condition Branch Retinal Vein Occlusion With Macular Edema
Treatment Aflibercept Injection [Eylea], Ranibizumab Injection [Lucentis]
Clinical Study IdentifierNCT03709745
SponsorSt. Erik Eye Hospital
Last Modified on25 September 2022

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