LCCC 2044: Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC
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- STATUS
- Recruiting
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- End date
- Nov 19, 2025
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- participants needed
- 220
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- sponsor
- UNC Lineberger Comprehensive Cancer Center
Summary
The primary goal of this study is to examine whether recurrence of HPV-associated OPSCC can be predicted by two factors: 1) mutations in genes called TRAF3 and CYLD, and 2) measurements of circulating HPV DNA in blood plasma. The study will also investigate whether HPV integration is associated with TRAF3 and CYLD mutations, and whether recurrence prediction improves when looking at HPV integration along with TRAF3 and CYLD mutations.
Details
| Condition | Oropharyngeal Squamous Cell Carcinoma, Carcinoma, Squamous Cell, Head and Neck Squamous Cell Carcinoma, Oropharynx Squamous Cell Carcinoma |
|---|---|
| Clinical Study Identifier | NCT04564989 |
| Sponsor | UNC Lineberger Comprehensive Cancer Center |
| Last Modified on | 19 October 2022 |
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