Right Ventricular Diastolic Dysfunction

  • STATUS
    Recruiting
  • End date
    Jun 1, 2022
  • participants needed
    30
  • sponsor
    University Hospital, Montpellier
Updated on 26 January 2021

Summary

Heart-lung interactions remain misunderstood whereas pulmonary and cardiac pathologies are very commonly associated.

Emphysema by increasing intrathoracic pressure appears to affect cardiac function.

Interestingly, previous studies have shown a link between the telediastolic volume of the right ventricle (measured by RMI) and the intensity of emphysema.

Our hypothesis is that the emphysema by increasing intrathoracic pressure leads to or accentuates right cardiac diastolic dysfunction by decreasing compliance and cardiac preload.

To verify this hypothesis the investigators will perform KT loop procedures in order to acquire intracardiac pressure/volume curves before and after lung volume reduction.

The pressure/volume curves allow the analysis of systolic and diastolic function, cardiac contractility and loading conditions.

Details
Condition Chronic Obstructive Lung Disease, Emphysema, Emphysema, COPD (Chronic Obstructive Pulmonary Disease), Reactive Airway Disease, chronic obstructive pulmonary disease, COPD, chronic obstructive pulmonary disease (copd), Right Heart Dysfunction
Clinical Study IdentifierNCT04467242
SponsorUniversity Hospital, Montpellier
Last Modified on26 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age greater than or equal to 40 yrs?
Gender: Male or Female
Do you have any of these conditions: chronic obstructive pulmonary disease (copd) or Reactive Airway Disease or chronic obstructive pulmonary disease or Chronic Obstructive Lung Disease o...?
Do you have any of these conditions: COPD or Emphysema or Right Heart Dysfunction or chronic obstructive pulmonary disease (copd) or COPD (Chronic Obstructive Pulmonary Disease) or Chroni...?
Do you have any of these conditions: Emphysema or COPD (Chronic Obstructive Pulmonary Disease) or Reactive Airway Disease or chronic obstructive pulmonary disease (copd) or Right Heart Dy...?
At least 40 years
A smoking history
Smoking cessation 6 months
FEV1/FVC 0,7
Severe emphysema (destruction 50%)
Peak tricuspid regurgitation velocity < 2,8 m/s or presence of other echocardiographic "PH signs
% FEV1post 50%
Residual volume 175% predicted
TLC 100% predicted
Optimal medical management
m 6MWD 500m
mMRC 2
Physical activity 2/Week ( 30minutes)

Exclusion Criteria

hospitalizations/year for EACOPD
Recent EACOPD ( 3months)
ml mucus/day
PAPm 35mmHg
PaCO2 55mmHg
Bubble 1/3 hemithorax
Lung fibrosis, bronchiectasis, lung cancer, homolateral surgery
Left ventricular ejection fraction 45%, unstable heart disease
Life expectancy 1 year
Contraindication to anesthesia
Allergy to nitinol or silicone
Corticotherapy 10mg/day
Patient under legal protection
Clear my responses

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