Bone Erosions in Rheumatoid Arthritis - Characterization Evaluated by Imaging and Histology

  • STATUS
    Recruiting
  • End date
    Nov 28, 2035
  • participants needed
    10
  • sponsor
    University of Aarhus
Updated on 28 January 2021

Summary

The aim of this study is to describe macro- and micro anatomical structures, including investigating vessels running in osseous pores in finger joints from participants with rheumatoid arthritis (RA) using histology and different imaging modalities. The perspectives are to increase understanding of the macro- and micro anatomic basis for bone erosions in RA, and possibly to provide new insights to the monitoring of patients with RA.

Description

This study is a descriptive, cross-sectional pilot study. The trial subjects will have their hands imaged by conventional radiography. The 2nd and 3rd digit metacarpophalangeal (MCP) joint will be scanned by high-resolution peripheral quantitative computed tomography (HR-pQCT). Patients with RA (n = 10) will be included and bone samples from MCP joints analyzed using microcomputed tomography (CT) and histology.

ELIGIBILITY CRITERIA

Inclusion criteria:

  • Age > 18 years.
  • Participants diagnosed with RA according to the ACR/EULAR (2010) classification criteria or American Rheumatism Association 1987 revised criteria for the patients who were diagnosed before 2010.
  • Indication for prosthesis surgery with total joint replacement of the MCP joint according to the clinical procedure (often radiological signs of osteoarthrosis (OA) in the MCP joint, joint pain, angular deformity and/or impairment of daily functions).

Details
Condition Rheumatoid Arthritis, Rheumatoid Arthritis, Rheumatoid Arthritis (Pediatric), Rheumatoid Arthritis (Pediatric)
Clinical Study IdentifierNCT04645381
SponsorUniversity of Aarhus
Last Modified on28 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Age > 18 years
Participants diagnosed with RA according to the ACR/EULAR (2010) classification criteria or American Rheumatism Association 1987 revised criteria for the patients who were diagnosed before 2010
Indication for prosthesis surgery with total joint replacement of the MCP joint according to the clinical procedure (often radiological signs of OA in the MCP joint, joint pain, angular deformity and/or impairment of daily functions)

Exclusion Criteria

Unable to give written informed consent
Active malignant disease, hypercalcemia, poor kidney function (estimated glomerular filtration rate < 35 mL/min), untreated hypo-/hyperthyroidism, pregnancy or wish thereof, previously fracture/dislocation of the investigated joint or metal prosthesis in joints of the investigated hand
Bone sample will be excluded from analysis, if the following is present
Bone not adequate for analysis (fractured bone samples)
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