The Olmsted NAFLD Epidemiology Study (TONES)

  • End date
    Jun 1, 2026
  • participants needed
  • sponsor
    Mayo Clinic
Updated on 3 December 2020


Researchers are assessing the prevalence of Non-alcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH) in the population and assembling a well-characterized cohort of adults with NAFLD and NASH to determine long-term outcomes.


Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common cause of chronic liver disease in the world and a major public health issue in the US (1) (2). Epidemiologic studies assessing the prevalence of NAFLD in the general population have been largely based on NHANES surveys between 1988 and 1992 (3), or single center hepatology evaluation, which is limited by selection bias. Obesity rates have increased significantly since early 1990s (4), therefore the prevalence of NAFLD has likely changed. Recent information on the prevalence of NAFLD in general and Non-Alcoholic Steatohepatitis (NASH) with fibrosis in particular is very scarce. Such information is crucial for defining the epidemiology of NAFLD, identifying risk factors for advanced fibrosis and longitudinal outcomes. These data would be fundamental for the development of screening strategies in the community, which are urgently needed for early diagnosis of liver fibrosis and therapeutic interventions before cirrhosis develops.

Treatment Blood draw, Liver biopsy, Magnetic Resonance Elastography
Clinical Study IdentifierNCT04365855
SponsorMayo Clinic
Last Modified on3 December 2020

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Inclusion Criteria

Is your age greater than or equal to 18 yrs?
Gender: Male or Female
Do you have any of these conditions: Non Alcoholic Fatty Liver Disease or Nonalcoholic Fatty Liver Disease or Non-alcoholic Fatty Liver Disease or Non Alcoholic Steatohepatitis or non-alc...?
Do you have any of these conditions: Nonalcoholic Steatohepatitis (NASH) or non-alcoholic fatty liver or Non Alcoholic Fatty Liver Disease or Nonalcoholic Fatty Liver Disease or Non-alcoh...?
Adults age 18 years or older
Olmsted County residents at the time of survey

Exclusion Criteria

Pediatric population (age<18)
Unwilling to participate or unable to consent
Known liver disease other than NAFLD at the time of survey
Pregnant women
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Step 4 Get your study results

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