Researchers are assessing the prevalence of Non-alcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH) in the population and assembling a well-characterized cohort of adults with NAFLD and NASH to determine long-term outcomes.
Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common cause of chronic liver disease in the world and a major public health issue in the US (1) (2). Epidemiologic studies assessing the prevalence of NAFLD in the general population have been largely based on NHANES surveys between 1988 and 1992 (3), or single center hepatology evaluation, which is limited by selection bias. Obesity rates have increased significantly since early 1990s (4), therefore the prevalence of NAFLD has likely changed. Recent information on the prevalence of NAFLD in general and Non-Alcoholic Steatohepatitis (NASH) with fibrosis in particular is very scarce. Such information is crucial for defining the epidemiology of NAFLD, identifying risk factors for advanced fibrosis and longitudinal outcomes. These data would be fundamental for the development of screening strategies in the community, which are urgently needed for early diagnosis of liver fibrosis and therapeutic interventions before cirrhosis develops.
|Treatment||Blood draw, Liver biopsy, Magnetic Resonance Elastography|
|Clinical Study Identifier||NCT04365855|
|Last Modified on||3 December 2020|
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