The Olmsted NAFLD Epidemiology Study (TONES)

  • STATUS
    Recruiting
  • End date
    Jun 1, 2026
  • participants needed
    1000
  • sponsor
    Mayo Clinic
Updated on 18 February 2021

Summary

Researchers are assessing the prevalence of Non-alcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH) in the population and assembling a well-characterized cohort of adults with NAFLD and NASH to determine long-term outcomes.

Description

Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common cause of chronic liver disease in the world and a major public health issue in the US (1) (2). Epidemiologic studies assessing the prevalence of NAFLD in the general population have been largely based on NHANES surveys between 1988 and 1992 (3), or single center hepatology evaluation, which is limited by selection bias. Obesity rates have increased significantly since early 1990s (4), therefore the prevalence of NAFLD has likely changed. Recent information on the prevalence of NAFLD in general and Non-Alcoholic Steatohepatitis (NASH) with fibrosis in particular is very scarce. Such information is crucial for defining the epidemiology of NAFLD, identifying risk factors for advanced fibrosis and longitudinal outcomes. These data would be fundamental for the development of screening strategies in the community, which are urgently needed for early diagnosis of liver fibrosis and therapeutic interventions before cirrhosis develops.

Details
Condition NAFLD, Non-alcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis (NASH), Nonalcoholic Fatty Liver Disease, Non Alcoholic Steatohepatitis, Non Alcoholic Fatty Liver Disease, Non-alcoholic Fatty Liver Disease, non-alcoholic fatty liver
Treatment Blood draw, Liver biopsy, Magnetic Resonance Elastography, fibro scan
Clinical Study IdentifierNCT04365855
SponsorMayo Clinic
Last Modified on18 February 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age greater than or equal to 18 yrs?
Gender: Male or Female
Do you have any of these conditions: Non Alcoholic Fatty Liver Disease or Nonalcoholic Fatty Liver Disease or Non-alcoholic Fatty Liver Disease or Non Alcoholic Steatohepatitis or non-alc...?
Do you have any of these conditions: Nonalcoholic Steatohepatitis (NASH) or non-alcoholic fatty liver or Non Alcoholic Fatty Liver Disease or Nonalcoholic Fatty Liver Disease or Non-alcoh...?
Do you have any of these conditions: non-alcoholic fatty liver or Non Alcoholic Steatohepatitis or Nonalcoholic Steatohepatitis (NASH) or Non-alcoholic Fatty Liver Disease or NAFLD or Non...?
Do you have any of these conditions: Non-alcoholic Fatty Liver Disease or Nonalcoholic Fatty Liver Disease or Nonalcoholic Steatohepatitis (NASH) or Non Alcoholic Steatohepatitis or Non A...?
Do you have any of these conditions: Non-alcoholic Fatty Liver Disease or Non Alcoholic Fatty Liver Disease or non-alcoholic fatty liver or Non Alcoholic Steatohepatitis or Nonalcoholic S...?
Adults age 18 years or older
Olmsted County residents at the time of survey

Exclusion Criteria

Pediatric population (age<18)
Unwilling to participate or unable to consent
Known liver disease other than NAFLD at the time of survey
Pregnant women
Clear my responses

How to participate?

Step 1 Connect with a site
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar
Name

Primary Contact

site
Name

Phone Email

0/250
Please verify that you are not a bot.

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Loading...

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 

 • 

Private

Reply by • Private
Loading...

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.
Loading...

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note