Opioid Free Anesthesia in Breast Cancer Surgery

  • STATUS
    Recruiting
  • End date
    Jul 28, 2022
  • participants needed
    78
  • sponsor
    Peking University People's Hospital
Updated on 28 January 2021

Summary

A comparison of incidences of postoperative nausea and vomiting (PONV) , postoperative pain severity and recovery parameters in breast cancer patients receiving opioid or opioid-free general anesthesia.

Description

Breast cancer is one of the most common oncologic diagnosis in women. Surgery is traditionally performed under general anesthesia with opioid-based analgesia. It is associated with higher incidences of PONV, more severe acute postoperative pain and increased incidences of chronic pain. The possibility of higher risk of metastasis has also been reported.

The purpose of our study is to compare the opioid-free general anesthesia with the opioid-based general anesthesia with respect to the quality of recovery, postoperative pain and cancer recurrence and metastasis.

Details
Condition Opioid Free Anesthesia
Treatment Sham block, paravertebral block, opioid free anesthesia, opioid general anesthesia
Clinical Study IdentifierNCT04390698
SponsorPeking University People's Hospital
Last Modified on28 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

first diagnosis of histologically confirmed primary breast cancer
undergoing radical mastectomy
patients with I or II staging based on TNM staging system
ASA physical statue I-II

Exclusion Criteria

chronic pain and opioid administration history
allergy to local anesthetics or NSAIDs
coagulation disorders
local infection at regional block site
unable to comply to study protocol schedule for logistic or other reasons
refusal to participate to the study
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