LUMINOS-102: Lerapolturev With or Without Immune Checkpoint Blockade in Advanced PD-1 Refractory Melanoma

  • STATUS
    Not Recruiting
  • End date
    May 12, 2023
  • participants needed
    56
  • sponsor
    Istari Oncology, Inc.
Updated on 18 April 2022

Summary

A Phase 2 study to investigate the efficacy and safety of lerapolturev alone or in combination with a programmed death receptor-1 (anti-PD-1) inhibitor.

Description

This multi-center, open-label, randomized, Phase 2 will investigate the efficacy and safety of lerapolturev alone (Arm 1) or in combination with an anti-PD-1 inhibitor (Arm 2). Following a 6 participant safety run-in period, up to approximately 50 participants with cutaneous melanoma who previously failed anti-PD-1/L1-based therapy will be randomized 1:1 to receive either lerapolturev or lerapolturev plus an anti-PD-1.

Details
Condition Melanoma
Treatment PVSRIPO, Anti-PD-1 Checkpoint Inhibitor, Lerapolturev
Clinical Study IdentifierNCT04577807
SponsorIstari Oncology, Inc.
Last Modified on18 April 2022

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