Multi Breath Nitrogen Washout (MBNW) as a Measure of Small Airway Function in Patients With Respiratory Disease

  • STATUS
    Recruiting
  • participants needed
    90
  • sponsor
    Bayside Health
Updated on 7 November 2020
Investigator
Bruce Thompson
Primary Contact
Alfred Hospital (2.3 mi away) Contact
cystic fibrosis
asthma
fibrosis
respiratory disorder
lung transplant
respiratory disease

Summary

The researchers are investigating a novel technique, the multi breath nitrogen washout technique, to measure airway changes in various respiratory diseases.

Description

It is well documented that there are significant ventilatory changes in respiratory diseases such as cystic fibrosis, asthma and the onset of bronchiolitis obliterans syndrome (BOS) following chronic rejection of lung transplantation. At present, we use measures such as spirometry and lung biopsies to determine the changes of airway function and disease severity. Our aim is to develop a novel technique called the multi breath nitrogen washout (MBNW) which we believe is able to measure the inhomogeneity of ventilation in both the larger airways (conductive region, generation 1 - 16) as well as the smaller airways (acinar region 17 - 23). Our belief is that these measurements are much more subtle than current techniques and will be more sensitive in measuring large and small airway changes in disease. The MBNW can also give us an insight as to which particular zones of the lung are affected in differing respiratory disease. For example, it is believed that BOS begins at the distal portion of the lung (acinar region) and proceeds towards the proximal zone (conductive). However, at present no current techniques can differentiate between damage to the acinar zone and the conductive zone or indeed accurately measure small airway (acinar zone) function. We believe the the MBNW has the capacity to do so.

Details
Condition Cystic Fibrosis, Lung transplant, Bronchiolitis Obliterans, Asthma
Clinical Study IdentifierNCT00163696
SponsorBayside Health
Last Modified on7 November 2020

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