Combi-elastography Assessment of HCC Recurrence After Thermal Ablation Multi-center Study

  • End date
    May 31, 2024
  • participants needed
  • sponsor
    Chinese PLA General Hospital
Updated on 2 February 2021


Combined F index, A index,ATT index and spleen stiffness to predict tumor recurrence in different liver settings after thermal ablation of HCC.


Thermal ablation is one of the established method for HCC treatment. Postoperative recurrence of HCC is one of the major factors leading to poor prognosis of HCC patients. Most studies have shown that the risk factors of recurrence include tumor size, tumor number and intrahepatic spread, etc.

Besides, the carcinogenic effects of inflammatory activity and fibrosis in liver background caused by chronic hepatitis also be related to the recurrence. In the study, combi-elastography imaging technology , not only the F index which is related to liver fibrosis stage can be obtained, but also the A index which is related to inflammation activity can be measured, this may provide a more valuable method for tumor recurrence of early prediction.

Condition HEPATOCELLULAR CARCINOMA, Recurrent Tumor, Recurrence Tumor, Tumor Recurrence, neoplasm recurrence, liver cell carcinoma, the Predictive Power of Combined Elastography for Tumor Recurrence in Different Liver Settings After Thermal Ablation of HCC
Clinical Study IdentifierNCT04640363
SponsorChinese PLA General Hospital
Last Modified on2 February 2021


Yes No Not Sure

Inclusion Criteria

Aged 18 to 80 years of age, and gender not limited;Chronic hepatitis B patients;The lesions of liver have the histopathological diagnosis of HCC and within MiLan criteria;All lesions were performed thermal ablation surgery;Sign the informed consent

Exclusion Criteria

Lesions that unrealized complete inactivation evaluation by the enhanced imaging;Merging other systems' serious illness that can't cooperate with elastic imaging checking(such as heart failure, renal failure, such as mental illness);After liver transplantation patients;Patients with pregnancy
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