Metabolism Informed Smoking Treatment: The MIST RCT
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- STATUS
- Recruiting
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- End date
- Nov 24, 2026
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- participants needed
- 1000
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- sponsor
- Vanderbilt-Ingram Cancer Center
Summary
This phase 3 randomized controlled trial will test Metabolism-Informed Smoking Treatment (MIST), a precision approach to smoking treatment that biologically tailors medication selection to nicotine metabolism.
Description
This is a randomized controlled trial to compare effects of MIST versus usual care (UC) interventions on the outcomes below.
- Objectives
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- Abstinence as defined by biochemically-verified self-reported 7-day point prevalence abstinence at 6 m (1° study outcome) and 12 m (2° outcome).
- Clinical practice implementation as measured by participant self-reported medication adherence at months 1 and 3, self-reported receipt of prescription for smoking cessation medication after hospital discharge, and whether the prescription was tailored to the NMR result.
Exploratory Objective:
- Longitudinal assessment of health care utilization visits (ER and hospitalization) for 12 months following hospital discharge.
Details
| Condition | Smoking |
|---|---|
| Treatment | Varenicline, Nicotine Replacement Therapy, Post-discharge automated phone calls (IVR) with option to connect with a tobacco coach., Metabolism Informed Smoking Treatment (Nicotine metabolite ratio (NMR)-based selection of pharmacotherapy) |
| Clinical Study Identifier | NCT04590404 |
| Sponsor | Vanderbilt-Ingram Cancer Center |
| Last Modified on | 4 October 2022 |
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