Nefopam for Post Video-Assisted Thoracoscopic Lobectomy Pain Management and the Improvement of Enhanced Recovery After Surgery (ERAS): A Randomized Controlled Trial

  • STATUS
    Recruiting
  • End date
    Mar 14, 2023
  • participants needed
    92
  • sponsor
    Mahidol University
Updated on 14 October 2022
Accepts healthy volunteers

Summary

Video-assisted thoracoscopic (VATs) lobectomy is mild to moderately pain procedure. For conventional thoracotomy, there are many invasive pain control such as epidural analgesia, paravertebral block. However, for VATs, the invasive pain control somehow are too invasive. Nefopam is non-opioid painkilling medication, Serotonin, norepinephrine, dopamine reuptake inhibitor. Many study were demonstrated positive outcome of nefopam usage in many operation such as abdominal surgery, laparocopic surgery, orthopedic surgery. Nevertheless, nefopam for VATs is not well studied yet.

Details
Condition Pain, Postoperative
Treatment Placebo, Nefopam 20 MG/ML, Nefopam 20 MG/ML
Clinical Study IdentifierNCT04241640
SponsorMahidol University
Last Modified on14 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Schedule to video-assisted thoracoscopic surgery : VATs lobectomy
Can operate a patient-controlled analgesia (PCA) device
No contraindication for nefopam

Exclusion Criteria

Epilepsy, on monoamine oxidase (MAO) inhibitors, glaucoma
Creatinine clearance < 60 ml/min
Liver disease: child-pugh score B or C
Allergy to nefopam
Chronic opioid use
Clear my responses

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