Understanding of Psychotic Disorders in Children With 22q11.2DS (PremiCeS22)

  • End date
    Jan 31, 2025
  • participants needed
  • sponsor
    Hôpital le Vinatier
Updated on 23 March 2022
Accepts healthy volunteers


The study PremiCeS22 will investigate the prodromal signals at the onset of psychotic disorders of children with 22q11.2 deletion syndrome


22q11.2DS is one of the most common microdeletion syndromes (1 / 2000-1 / 4000 births) and one of the most robust genetic risk factors for schizophrenia (1 to 2% of cases). Reciprocally, approximately 30% of patients with 22q11.2DS will develop psychotic symptoms in adolescence or early adulthood. It is now well established that children and adults with 22q11.2DS have lower social skills than developing youth. These social dysfunctions could be partly underpinned by alterations in social cognitive processes, and could also be linked to the emergence of psychotic signs or even schizophrenia. However, to our knowledge, no study has investigated the existence of behavioral prodromal signs during the onset of psychotic signs in children with 22q11.2DS. In addition, the origin of social cognitive processes remains to this day little explored.

Condition 22q11.2 Deletion Syndrome
Treatment neuropsychological testing, questionnaires and experimental tasks
Clinical Study IdentifierNCT04639388
SponsorHôpital le Vinatier
Last Modified on23 March 2022


Yes No Not Sure

Inclusion Criteria

Diagnosis of 22q11.2 deletion syndrome or no developmental disease
Aged from 4 to 13 years old
French language

Exclusion Criteria

Diagnosis of intellectual deficiency according to DSM 5 criteria
Drug prescribed for somatic condition that could influence cerebral functioning
Clear my responses

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