Evaluation of tDCS Efficacy in Enduring Anorexia Nervosa

  • End date
    Mar 7, 2023
  • participants needed
  • sponsor
    Centre Hospitalier Universitaire de Saint Etienne
Updated on 7 August 2021


Approximately 20% of anorexia nervosa cases do not respond to conventional management strategies: cognitive behavioral therapy, weight gain contract, drug treatments, etc ... - whether they are applied outpatients or during very long hospitalizations. These situations of chronic evolution are characterized by a high rate of mortality. Brain stimulation could be an alternative therapy for these patients. tDCS (transcranial direct current stimulation) is a non-invasive stimulation technique that has demonstrated beneficial effects in other psychiatric conditions such as major depression or schizophrenia.

The objectives of the study will be to evaluate the efficacy of tDCS in anorexia nervosa resistant to conventional treatments on weight gain, eating behavior, psychological and nutritional behavioral scales, cognition, connectivity and brain activity.

Condition Anorexia Nervosa
Treatment Transcranial direct current stimulation (tDCS)
Clinical Study IdentifierNCT03813355
SponsorCentre Hospitalier Universitaire de Saint Etienne
Last Modified on7 August 2021


Yes No Not Sure

Inclusion Criteria

Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 anorexia nervosa criteria
Body Mass Index (BMI) < 17kg/m2
Conventional treatment failure over the last 12 months
Refusal or no indication of artificial nutrition

Exclusion Criteria

Artificial nutrition
Other chronic diseases
drug use (except tobacco)
Edinburgh score < 14
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