Observational Study on Patients With Hepatobiliary Tumors

  • End date
    Dec 1, 2023
  • participants needed
  • sponsor
    Gang Chen, MD
Updated on 26 January 2021


Hepatobiliary tumors have a poor prognosis and high individual heterogeneity, the patient with hepatobiliary tumors even accepted radical surgery, the postoperative recurrence rate is still high. Therefore, it is of great significance to find important prognostic markers to improve patient prognosis and formulate new treatment plans after surgery. In recent years, targeted therapy and immunotherapy make cancer treatment enter a new field, However, tumor heterogeneity is the greatest challenge in cancer therapeutics and biomarkers discovery. In this study, we obtained blood and pathological tissue specimens from tumor patients, then Multi-omics testing were applied to Looking for novel therapeutic targets and prognostic markers to predict patient response to treatment. Clinicians choose the best treatment plan for the patient based on the test results to improve the patient's survival time and quality of life.


This is an ongoing, longitudinal, single centre, observational clinical cohort study of patients with hepatobiliary tumors. All the patients are diagnosed, treated and followed up by The First Affiliate hospital of Wenzhou medical university.

Condition Adenocarcinoma, Cholangiocarcinoma, Biliary neoplasm, HEPATIC NEOPLASM, HEPATOCELLULAR CARCINOMA, Malignant neoplasm of gallbladder, Gallbladder Disease, Gallbladder Carcinoma, Urothelial Tract Cancer, Gall Bladder Disorders, Liver Cancer, Malignant Adenoma, Gall Bladder Cancer, Biliary Tract Cancer, gallbladder cancer, liver cell carcinoma, biliary cancer
Clinical Study IdentifierNCT04637048
SponsorGang Chen, MD
Last Modified on26 January 2021


Yes No Not Sure

Inclusion Criteria

Be older than 18 years old
Clinical or pathological diagnosis of malignant hepatobiliary tumors
Patients have received or are about to receive surgery, chemotherapy radiotherapy, targeted therapy, local therapy, immunotherapy, etc
Patients understand and are willing to sign written informed consent

Exclusion Criteria

Patients considered by the doctor to be unsuitable for entry into this study (mental disorder or poor compliance, etc.)
The patient or guardian is unwilling to participate in this study
Pregnant women
Combined with other serious systemic diseases (heart failure, renal failure,hematopoietic system disease or Uncontrollable acute infection)
Estimated survival time is less than 1 month
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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