Losartan for Improved Vascular Endothelial Function After Preeclampsia (LIVE-PE)

  • End date
    Jul 16, 2025
  • participants needed
  • sponsor
    Anna Stanhewicz, PhD
Updated on 16 September 2023


Women who develop preeclampsia during pregnancy are more likely to develop and die of cardiovascular disease later in life, even if they are otherwise healthy. The reason why this occurs is unclear but may be related to blood vessel damage and increased inflammation that occurs during the preeclamptic pregnancy and persists postpartum. The purpose of this investigation is to determine the mechanisms contributing to this lasting blood vessel damage and to test whether taking a medication that blocks angiotensin II receptors (losartan) decrease these negative effects in women who have had preeclampsia. Identification of these mechanisms and treatment strategies may lead to better clinical management,of cardiovascular disease risk in these women.

In this study we use the blood vessels in the skin as a representative vascular bed. Using a minimally invasive technique (intradermal microdialysis for the local delivery of pharmaceutical agents) we examine the blood vessels in a nickle-sized area of the skin in women who have had preeclampsia. We make these measurements after the subjects take a placebo and after they take losartan (an angiotensin II receptor blocker) to test whether this treatment improves vascular function in these women. As a compliment to these measurements, we also draw blood from the subjects and isolate the inflammatory cells to test how sensitive their inflammatory responses are following the placebo and the losartan treatment.

Condition Preeclampsia Postpartum
Treatment Placebo, Losartan Potassium
Clinical Study IdentifierNCT04632589
SponsorAnna Stanhewicz, PhD
Last Modified on16 September 2023


Yes No Not Sure

Inclusion Criteria

Post-partum women
years or older
who have delivered within 24 months of the study visit
who have had a preeclamptic pregnancy diagnosed by their obstetrician and confirmed according to the American College of Obstetricians and Gynecologists criteria for preeclampsia. [This information will be self-reported by the subjects.]
Using an effective method of birth control and not planning to become pregnant in the next 6 months

Exclusion Criteria

skin diseases
current tobacco use
diagnosed or suspected hepatic or metabolic disease including chronic kidney disease (CKD) defined as reduced eGFR < 60 mL/min/1.73m2
statin or other cholesterol-lowering medication
current antihypertensive medication
history of hypertension prior to pregnancy
history of gestational diabetes
current pregnancy or breastfeeding
body mass index <18.5 kg/m2
allergy to materials used during the experiment.(e.g. latex)
known allergies to study drugs
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