Chronic Pain Master Protocol (CPMP): A Study of LY3556050 in Participants With Osteoarthritis

  • STATUS
    Recruiting
  • End date
    Dec 29, 2021
  • participants needed
    200
  • sponsor
    Eli Lilly and Company
Updated on 12 September 2021
body mass index
chronic pain
x-rays
knee pain

Summary

This study is being done to test the safety and efficacy of LY3556050 for the treatment of osteoarthritis pain. This trial is part of the chronic pain master protocol (H0P-MC-CPMP) which is a protocol to accelerate the development of new treatments for chronic pain.

Details
Condition Arthritis, Osteoarthritis, Arthritis and Arthritic Pain, Arthritis and Arthritic Pain (Pediatric), degenerative arthritis
Treatment Placebo, LY3556050
Clinical Study IdentifierNCT04627038
SponsorEli Lilly and Company
Last Modified on12 September 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Have a visual analog scale (VAS) pain value 40 and <95 during screening
Have a history of daily pain for at least 12 weeks based on participant report or medical history
Have a body mass index <40 kilograms per meter squared (kg/m) (inclusive)
Are willing to maintain a consistent regimen of any ongoing nonpharmacologic pain-relieving therapies (for example, physical therapy) and will not start any new nonpharmacologic pain-relieving therapies during study participation
Are willing to discontinue all medications taken for chronic pain conditions for the duration of the study
Have presence of index knee pain for >12 weeks at screening
Have an x-ray supporting diagnosis of osteoarthritis according to the American College of Rheumatology with a Kellgren-Lawrence grade 2 to 4 radiographic classification of index knee
Are men, or women able to abide by reproductive and contraceptive requirements

Exclusion Criteria

Have second- or third-degree atrioventricular (AV) heart block or AV dissociation or history of ventricular tachycardia
Have had a procedure within the past 6 months intended to produce permanent sensory loss in the target area of interest (for example, ablation techniques)
Have surgery planned during the study for any reason, related or not to the disease state under evaluation
Have, in the judgment of the investigator, an acute, serious, or unstable medical condition or a history or presence of any other medical illness that would preclude study participation
Have had cancer within 2 years of baseline, except for cutaneous basal cell or squamous cell carcinoma resolved by excision
Have a substance use disorder as defined by the Diagnostic and Statistical Manual of Mental Disorders (5th edition; DSM-5; American Psychiatric Association)
Have a positive human immunodeficiency virus (HIV) test result at screening
Are in the judgment of the investigator, actively suicidal and therefore deemed to be at significant risk for suicide
Have an intolerance to acetaminophen or paracetamol or any of its excipients
Have a history of alcohol, illicit drug, analgesic or narcotic use disorder within 2 years prior to screening
Are largely or wholly incapacitated and unable to participate fully in all protocol procedures, for example, bedridden or confined to a wheelchair, permitting little or no selfcare
Have presence of surgical hardware or other foreign body in the index knee
Have an unstable index joint (such as a torn anterior cruciate ligament)
Have had a surgical procedure or therapeutic injection in the affected knee within 3 months prior to starting the washout period
Have fibromyalgia, chronic pain syndrome, or other concurrent medical or arthritic conditions that could interfere with the evaluation of the index knee
Have a history of Reiter's syndrome, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, arthritis associated with inflammatory bowel disease, sarcoidosis, or amyloidosis
Have clinical signs and symptoms of active knee infection or crystal disease of the index knee
Have a history of infection in the index joint
Have a history of arthritis due to crystals (e.g., gout, pseudogout)
Have pain or functional impairment due to ipsilateral hip osteoarthritis
Have a history within 2 years prior to screening or current evidence of syncope, presyncope, uncontrolled vertigo, or postural dizziness, judged to be clinically significant by the investigator
Have clinically significant active thyroid disease, including Hashimoto's thyroiditis
Are taking metformin therapy
Are pregnant or breastfeeding
Have had any joint replacement such as knee of the lower extremity, such as hip, knee or ankle, in the past 6 months
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