Ketamine for Acute Pain Management After Trauma

  • End date
    May 30, 2022
  • participants needed
  • sponsor
    The University of Texas Health Science Center, Houston
Updated on 26 January 2021


The purpose of this study is to compare the effectiveness of Ketamine drip along with usual care and usual care alone on trauma patients and to longitudinally quantify the pain experience of patients during hospitalization.

Condition Pain, Post-Surgical Pain, Pain (Pediatric), Pain, Acute Pain Service, Post-Surgical Pain, Trauma Injury, Opioid Use, Pain (Pediatric), Narcotic Use, Injury Trauma, ache
Treatment Usual Care, Ketamine plus usual care
Clinical Study IdentifierNCT04129086
SponsorThe University of Texas Health Science Center, Houston
Last Modified on26 January 2021


Yes No Not Sure

Inclusion Criteria

Adult trauma patients
Admission to Shock Trauma ICU (STICU) or Surgical Intermediate Unit (SIMU)
Randomization within 6 hours of arrival

Exclusion Criteria

Patient not expected to survive
Contraindications to ketamine Allergy, Poorly controlled hypertension, Cardiac arrhythmia disorders (including atrial fibrillation), congestive heart failure, unstable coronary artery disease or recent myocardial infarction( MI)(within 6 months), cirrhosis, seizure disorder, and for those patients with unknown medical history - median sternotomy scar, mechanism of injury is fall from standing, 65 years of age or older, any arrhythmia on EKD)
in police custody
history of dementia or movement disorder (i.e. Parkinson's)
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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