Bimodal and Coaxial High Resolution Ophtalmic Imaging

  • End date
    Oct 15, 2024
  • participants needed
  • sponsor
    Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Updated on 26 January 2021


The knowledge of the pathogenesis of retinal affections, a major cause of blindness, has greatly benefited from recent advances in retinal imaging. However, optical aberrations of the ocular media limit the resolution that can be achieved by current techniques.

The use of an adaptive optics system improves the resolution of ophthalmoscopes by several orders of magnitude, allowing the visualization of many retinal microstructures: photoreceptors, vessels, bundles of nerve fibers.

Recently, the development of the coupling of the two main imaging techniques, the Adaptive Optics Ophthalmoscope with Optical Coherence Tomography, enables unparalleled three-dimensional in vivo cell-scale imaging, while remaining comfortable for the patients.

The purpose of this project is to evaluate the performance of this system for imaging micrometric retinal structures.


The goal of the project is the capture and analysis of images with AOSLO system, in order to evaluate the performance of this system compared to OCT imaging devices and existing Adaptive Optics used at National Hospital of Ophthalmology.

Condition NIDDM, Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2, Diabetes Mellitus, Diabetes Mellitus Types I and II, Diabetes Prevention, Diabetes (Pediatric), Retinal Detachment, Retinal Degeneration, Vascular Diseases, Vascular Diseases, Hypertension, High Blood Pressure (Hypertension), High Blood Pressure (Hypertension - Pediatric), Diabetes and Hypertension, Cerebrovascular accident, Stroke, Ocular Hypertension, Ocular Hypertension, Glaucoma, Glaucoma, Macular Edema, Cystoid Macular Edema, Macular Edema, age-related macular degeneration, Macular Degeneration, Retinitis Pigmentosa, Retinitis Pigmentosa, Diabetes Mellitus, Type 2, Diabetes Prevention, Diabetes and Hypertension, Diabetes Mellitus Types I and II, High Blood Pressure (Hypertension), High Blood Pressure (Hypertension - Pediatric), Vascular Inflammation, Maculopathy, Diabetes (Pediatric), Elevated Blood Pressure, Cystoid Macular Edema, Macular Degeneration, Stroke, Diabetes Mellitus Type 2, Diabetes, type 2 diabetes mellitus, high blood pressure, arterial hypertension, detached retina, diabetes mellitus (dm), type 2 diabetes, type ii diabetes, noninsulin-dependent diabetes mellitus, diabetes type 2, cerebrovascular accidents, strokes, cerebral
Treatment Bimodal high resolution imaging of the retina
Clinical Study IdentifierNCT04620876
SponsorCentre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Last Modified on26 January 2021


Yes No Not Sure

Inclusion Criteria

People over 18
Patient with a pathology affecting the eye or healthy volunteer
Participant who signed the consent
Beneficiaries of the health insurance

Exclusion Criteria

Patients with a history of photosensitivity
Patients who have just received a photodynamic therapy treatment
Patients taking drugs with photosensitivity as a side effect
Persons with pacemakers or other implanted electronic medical device
Patients with viral conjunctivitis or any other infectious disease
Patients with skin lesions on the neck or forehead
Patients at high risk of damage from optical radiation, such as aphakic patients, or patients with decreased sensitivity to light due to fundus disease
Participant unable to be followed throughout the study
Advanced cataract or severe opacities in the anterior segment of the eye
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note