A Trial of Anlotinib Combined With Docetaxel in Patients With Wild-type Advanced Non-squamous Non Small Cell Lung Cancer

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    Shandong Cancer Hospital and Institute
Updated on 26 January 2021


Anlotinib is a multi-target receptor tyrosine kinase inhibitor under domestic research and development. It can inhibit angiogenesis-related kinases, such as VEGFR, FGFR, PDGFR and tumor cell proliferation related kinase c-Kit kinase. In the Phase III study, patients who failed at least two systemic chemotherapy (third-line or above) or were intolerant of the drugs were treated with anlotinib or placebo. The PFS and OS in the anlotinib group were 5.37 months and 9.63 months, respectively. The placebo group PFS and OS were 1.4 months and 6.3 months. Therefore, it is envisaged to use anlotinib combined with docetaxel to treat wild-type advanced non-squamous non small cell lung cancer to further improve the patient's PFS or OS.


This is a single arm clinical trial conducted in China. The purpose of this study is to assess the efficacy and safety of Anlotinib Hydrochloride (12mg, QD PO d1-14, 21days per cycle) combined with Docetaxel (75mg/m2 IV d1) in the treatment of wild-type advanced non-squamous non small cell lung cancer patients with progression after immunotherapy plus chemotherapy as first-line treatment. After being informed about the study and potential risks, all patients giving written informed consent will undergo a 4-week screening period to determine eligibility for study entry. The expected sample size is 42.

Condition Non-Small Cell Lung Cancer, nsclc
Treatment Anlotinib Hydrochloride plus Docetaxel
Clinical Study IdentifierNCT04619537
SponsorShandong Cancer Hospital and Institute
Last Modified on26 January 2021


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Inclusion Criteria

The subjects voluntarily join the study and sign an informed consent form, with good compliance and cooperation with follow-up
EGFRALK mutation-negativePatients have progressed after receiving immunotherapy combined with platinum-based chemotherapy and have not used docetaxel. (Recurrent patients have previously received adjuvant chemotherapy and relapsed within six months.)
and 75 years of age; female or male
Diagnosed with local advanced and/or metastatic NSCLC (phase IIIBIIIC or IV) through Histology or cytology (using the new version of staging announced by the American Joint Committee on Cancer on January 1, 2018), or recurrent non- squamous non-small cell lung cancer
There is at least one target lesion that has not received radiotherapyand in at least one direction (the maximum diameter needs to be recorded)10 mm; the shortest diameter of the lymph node 15mm
Expected Survival Time: at least 3 months
The damage caused by prior treatment has been recovered (NCI-CTCAE 4.0 version classificationlevel 1)Receiving cytotoxic drugs, bevacizumab (Avastin),endostar, surgery 3 weeksRadiotherapy (except local palliative radiotherapy) 2 weeks
The main organs function are normally, the following criteria are met
Blood routine examination criteria should be met (no blood transfusion and blood products within 14 days): HB90 g/L; ANC 1.510^9/L; PLT8010^9/L
Biochemical examinations must meet the following criteria: TBIL<1.5ULN; ALT and AST < 2.5ULN, and for patients with liver metastases < 5ULN; Serum Cr 1.25ULN or endogenous creatinine clearance > 45ml/min (Cockcroft-Gault formula)
Women of childbearing potential must have taken reliable contraceptive measures or the result of serum or urine pregnancy test should be negative within 7 days prior to study enrollment, and willing to use and utilize an adequate method of contraception throughout treatment and for at least 8 weeks after the last test drug administration. Man participants should agree to use and utilize an adequate method of contraception throughout treatment and for at least 8 weeks after the last test drug administration or surgical sterilization

Exclusion Criteria

Squamous carcinoma of lung (including Adenosquamous carcinoma); Small cell lung cancer (including lung cancer mixed with small cell lung cancer and non- small cell lung cancer)
Previously used Anlotinib Hydrochloride, Docetaxel, Paclitaxel; Postoperative adjuvant treatment of taxanes is acceptable
Imaging (CT or MRI) shows that the distance between tumor lesion and the large blood vessel is 5 mm, or there is a central tumor that invades the local large blood vessel; or there is a significant pulmonary cavity or necrotizing tumor
Medical history and combined history
Significant brain metastases, cancerous meningitis, spinal cord compression, or imaging CT or MRI screening for brain or pia mater disease (a patient with brain metastases who have completed treatment and stable symptoms in 28 days before enrollment may be enrolled, but should be confirmed by brain MRI, CT or venography evaluation as no cerebral hemorrhage symptoms)
The patient is participating in other clinical studies
Other active malignancies that require simultaneous treatment
Patients with a history of malignant tumors except for patients with cutaneous basal cell carcinoma, superficial bladder cancer, cutaneous squamous cell carcinoma or orthotopic cervical cancer who have undergone a possible curative treatment and have no disease recurrence within 5 years from the start of treatment
Patients with previously systemic anti-tumor treatment-related adverse reactions (excluding hair loss) who have not recovered to NCI-CTCAE level 1
Abnormal blood coagulation (INR > 1.5 or prothrombin time (PT) > ULN + 4 seconds or APTT > 1.5 ULN), with bleeding tendency or undergoing thrombolytic or anticoagulant therapy; Note: Under the premise of prothrombin time international normalized ratio (INR) 1.5, low-dose heparin (adult daily dose of 0.6 million to 12,000 U) or low-dose aspirin (daily dosage 100 mg) is allowed for preventive purposes
Renal insufficiency: urine routine indicates urinary protein ++, or confirmed 24-hour urine protein 1.0g
The effects of surgery or trauma have been eliminated for less than 14 days before enrollment in subjects who have undergone major surgery or have severe trauma
Severe acute or chronic infections requiring systemic treatment
Suffering from severe cardiovascular disease: myocardial ischemia or myocardial infarction above grade II, poorly controlled arrhythmias (including men with QTc interval 450 ms, women 470 ms); according to NYHA criteria, grades III to IV Insufficient function, or cardiac color Doppler ultrasound examination indicates left ventricular ejection fraction (LVEF) <50%
Peripheral neuropathy with CTCAE degree 2 currently exists, except for trauma caused
Respiratory syndrome (CTC AE grade 2 dyspnea), serous effusion (including pleural effusion, ascites, pericardial effusion) requiring treatment
Long-term unhealed wounds or fractures
Decompensated diabetes or other ailments treated with high doses of glucocorticoids
Factors that have a significant impact on oral drug absorption, such as inability to swallow, chronic diarrhea, and intestinal obstruction
Clinically significant hemoptysis (daily hemoptysis greater than 50ml) within 3 months before enrollment; or significant clinically bleeding symptoms or defined bleeding tendency, such as gastrointestinal bleeding, hemorrhagic gastric ulcer, baseline fecal occult blood ++ and above, or suffering from vasculitis
Events of arterious/venous thrombosis occurring within 12 months prior to enrollment, such as cerebrovascular accidents (including transient ischemic attacks, cerebral hemorrhage, cerebral infarction), deep vein thrombosis, and pulmonary embolism
Planned for systemic anti-tumor therapy, including cytotoxic therapy, signal transduction inhibitors, immunotherapy (Or use mitomycin C within 6 weeks prior to receiving the test drug). Extended-field radiotherapy (EF-RT) was performed within 3 weeks before grouping or limited-field radiotherapy to be evaluated for tumor lesions within 2 weeks before grouping
Uncontrollable hypertension with two or more combined treatments (systolic blood pressure 145 mmHg or diastolic blood pressure 90 mmHg)
Have a history of psychotropic substance abuse and are unable to quit or have a mental disorder
Physical examination and laboratory examination findings
A known history of HIV testing positive or acquired immunodeficiency syndrome (AIDS)
untreated active hepatitis (hepatitis b: HBsAg positive and HBV DNA 500 IU/ml; Hepatitis c: HCV RNA is positive and liver function is abnormal); Combined with hepatitis b and hepatitis c infection
Other factors that may cause the study to be terminated midway according to the researchers' judgment, such as other serious diseases or severe laboratory test abnormalities or factors that will endanger patients' safety, or family or society factors of test data and sample collection
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