Lung Function Exercise Capacity and Serology Responses in Patients With COVID-19

  • STATUS
    Recruiting
  • End date
    Feb 17, 2025
  • participants needed
    700
  • sponsor
    Chinese University of Hong Kong
Updated on 2 September 2021

Summary

(a) Objectives

  1. To assess the full lung function, exercise capacity, quality of life in patients with COVID-19 over 2 years.
  2. To assess the longevity of the serology response to SARS-CoV2.
  3. To investigate the association of the neutralization titer in plasma from different vaccinated cohorts to its protection of infection using in vivo model
  4. To investigate the SARS-CoV-2 specific cellular and humoral immunities as well as their determinant factors from community subjects who have received different types of COVID-19 vaccines.
  5. To assess the third booster dose for subjects who have poor antibody response despite having received two doses of CoronaVac (Sinovac)

Description

The health conditions of adults (N=300) who recovered from varying severity of COVID-19 will be assessed and their blood are collected at 6, 12, 24 and 36 months after discharge. The assessment package includes: lung function tests, 6-min walk distance, chest radiographs/CT, and SF36 General Health questionnaire. Blood samples from community cohorts will be collected from before and up to 36 months after receiving one of the three COVID-19 vaccines (N=200 per vaccine type). The kinetics of SARS-CoV-2 specific humoral and cellular immunities from both convalescent and vaccinated cohorts are determined by neutralization assay and by measuring specific T cell responses upon stimulation of SARS-CoV-2 specific peptide library respectively. The antiviral level of the human plasma with various neutralization titer collected from different vaccinated cohorts will be tested in mouse model and ADCC assay.

Details
Condition pulmonary function tests, Respiratory physiology, quality-of-life, lung function tests, Quality of life, Exercise Capacity, lung function, COVID19, Pulmonary Function Test
Treatment Kaletra and beta interferon, third dose vaccination with CoronaVac vaccine, third dose vaccination with BionTech vaccine, Vaccination with Coronavac vaccine, Vaccination with BionTech Vaccine
Clinical Study IdentifierNCT04611243
SponsorChinese University of Hong Kong
Last Modified on2 September 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients who have been discharged from hospital following
treatment for COVID-19 -

Exclusion Criteria

Unwilling to be follow up
\-
Clear my responses

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