Study on the Effectiveness and Feasibility of Prone Position Ventilation Technology in Congenital Heart Disease

  • STATUS
    Recruiting
  • End date
    Jun 30, 2022
  • participants needed
    64
  • sponsor
    Children's Hospital of Fudan University
Updated on 25 January 2021

Summary

The purpose of this study was to compare the effects of conventional lying position and prone position ventilation on infants with acute lung injury after surgery for congenital heart disease. To explore the effectiveness and feasibility of prone position ventilation for children with acute lung injury after congenital heart disease surgery.

Description

The prone position has been used to treat severe hypoxemia in patients with acute respiration dysfunction syndrome (ARDS) since the 1970s, and it has significant effectiveness in improving gas exchange. Acute lung injury (ALI) is a common complication after congenital heart disease. The clinical manifestation is refractory hypoxemia. At present, mechanical ventilation is one of the main methods for the treatment of acute lung injury-induced respiratory distress syndrome. Prone position ventilation refers to placing the patient in the prone position during mechanical ventilation to expand the lungs in the atelectasis area and improve the ratio of lung ventilation and perfusion.

Prone position ventilation technology as an important lung protection ventilation strategy has been widely used clinically at home and abroad. Compared with adults, children are more convenient and easy to implement. Due to the exact mechanism of improving oxygenation function, the current domestic and foreign development of pediatric prone ventilation technology is mainly focused on children with ARDS. There are few studies on high-quality application effects after pediatric cardiac surgery, and almost no research has been carried out, especially for pediatric heart The indications for the implementation of the prone position after the disease surgery, the specific standardized process including the position angle, the prone duration plan, etc. all need to be studied. Therefore, there is an urgent need to develop prone position ventilation technology for critically ill children with congenital heart disease after surgery to reduce postoperative pulmonary complications and shorten the time of mechanical ventilation.

Details
Condition Investigative Techniques
Treatment Prone position ventilation technique
Clinical Study IdentifierNCT04607993
SponsorChildren's Hospital of Fudan University
Last Modified on25 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients with lung injury after congenital heart disease or chest X-ray CT suggest that pulmonary complications need to strengthen body drainage
Establish artificial airway, such as tracheal intubation
Children aged 0-12 months
Stable hemodynamics, more than 72 hours after surgery
Informed consent of family members

Exclusion Criteria

Unstable hemodynamics, severe hypotension, ventricular arrhythmia
Intracranial hypertension
Active acute bleeding
Spinal injuries and untreated unstable fractures, orthopedic surgery or recent abdominal surgery
Facial trauma
Severe pneumothorax
Delayed chest closure and wound infection, children who need to be immobilized
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